MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. (Q33762222)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24844244 AND SRC:MED&resulttype=core&format=json

18 March 2020

title

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells (English)

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18 March 2020

10

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18 March 2020

Junxia Min

11

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18 March 2020

16

Nathanael S Gray

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18 March 2020

author name string

Yubao Wang

1

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18 March 2020

Young-Mi Lee

2

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18 March 2020

Lukas Baitsch

3

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18 March 2020

Alan Huang

4

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18 March 2020

Yi Xiang

5

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18 March 2020

Haoxuan Tong

6

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18 March 2020

Ana Lako

7

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18 March 2020

Thanh Von

8

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18 March 2020

Christine Choi

9

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18 March 2020

Li Li

12

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18 March 2020

Frank Stegmeier

13

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18 March 2020

Robert Schlegel

14

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18 March 2020

Michael J Eck

15

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18 March 2020

Timothy J Mitchison

17

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18 March 2020

Jean J Zhao

18

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18 March 2020

language of work or name

English

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publication date

20 May 2014

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18 March 2020

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18 March 2020

volume

3

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18 March 2020

page(s)

e01763

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describes a project that uses

18 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4059381/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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PDK1 Protein Phosphorylation at Thr354 by Murine Protein Serine-Threonine Kinase 38 Contributes to Negative Regulation of PDK1 Protein Activity

22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target

22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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Basal-like breast cancer: a critical review

22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family

22 June 2018

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22 June 2018

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22 June 2018

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X chromosomal abnormalities in basal-like human breast cancer

22 June 2018

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Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase

22 June 2018

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Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

22 June 2018

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Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers

22 June 2018

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Substrate specificity and activity regulation of protein kinase MELK

22 June 2018

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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

22 June 2018

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FoxM1 is required for execution of the mitotic programme and chromosome stability

22 June 2018

1 reference

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An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

22 June 2018

1 reference

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Functional genetics and experimental models of human cancer

22 June 2018

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ONCOMINE: a cancer microarray database and integrated data-mining platform

22 June 2018

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

22 June 2018

1 reference

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Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1

22 June 2018

1 reference

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The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis

22 June 2018

1 reference

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A gene-expression signature as a predictor of survival in breast cancer

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

Gene expression profiling predicts clinical outcome of breast cancer

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

Molecular portraits of human breast tumours

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

Creation of human tumour cells with defined genetic elements

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

Activation of a novel human transforming gene, ret, by DNA rearrangement

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4059381

Maternal embryonic leucine zipper kinase is stabilized in mitosis by phosphorylation and is partially degraded upon mitotic exit

22 June 2018

1 reference

The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions.

21 January 2018

1 reference

Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series

21 January 2018

1 reference

Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells.

21 January 2018

1 reference

A functional analysis of MELK in cell division reveals a transition in the mode of cytokinesis during Xenopus development

21 January 2018

1 reference

Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas.

21 January 2018

1 reference

Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells

21 January 2018

1 reference

The humoral immune system has a key prognostic impact in node-negative breast cancer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24844244

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24844244

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.01763

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24844244 AND SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24844244 AND SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

24844244

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24844244 AND SRC:MED&resulttype=core&format=json