A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish (Q33758025)

29 July 2017

title

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish (English)

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29 July 2017

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4

Laure Bally-Cuif

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Christian Haass

5

object named as

Christian Haass

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author name string

Andrea Geling

1

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29 July 2017

Harald Steiner

2

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29 July 2017

Michael Willem

3

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29 July 2017

publication date

1 July 2002

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29 July 2017

number of pages

7

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inferred from page(s)

published in

EMBO Reports

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29 July 2017

volume

3

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29 July 2017

issue

7

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29 July 2017

page(s)

688-694

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APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

29 July 2017

cites work

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28 July 2018

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A portrait of Alzheimer secretases--new features and familiar faces

28 July 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

28 July 2018

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28 July 2018

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Presenilin-dependent gamma-secretase activity modulates thymocyte development

28 July 2018

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Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

28 July 2018

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28 July 2018

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Notch signaling: from the outside in

28 July 2018

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Notch signalling and the synchronization of the somite segmentation clock

28 July 2018

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28 July 2018

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Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

28 July 2018

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28 July 2018

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Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

28 July 2018

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Control of her1 expression during zebrafish somitogenesis by a delta-dependent oscillator and an independent wave-front activity

28 July 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

28 July 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

28 July 2018

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Mice lacking both presenilin genes exhibit early embryonic patterning defects

28 July 2018

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Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

28 July 2018

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A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

28 July 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

28 July 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

28 July 2018

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Control of neurogenesis--lessons from frogs, fish and flies

28 July 2018

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Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm

28 July 2018

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

28 July 2018

1 reference

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The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

28 July 2018

1 reference

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Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

28 July 2018

1 reference

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Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio.

28 July 2018

1 reference

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Mutations affecting somite formation and patterning in the zebrafish, Danio rerio.

28 July 2018

1 reference

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Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos

28 July 2018

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Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos

28 July 2018

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

28 July 2018

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Notch2: a second mammalian Notch gene

28 July 2018

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Presenilins and the intramembrane proteolysis of proteins: facts and fiction.

28 July 2018

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The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Zebrafish developmental genetics and central nervous system development.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Notch signalling and the control of cell fate choices in vertebrates.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

The activity of neurogenin1 is controlled by local cues in the zebrafish embryo.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Overexpression of a zebrafish homologue of the Drosophila neurogenic gene Delta perturbs differentiation of primary neurons and somite development

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Stages of embryonic development of the zebrafish

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Differential expression of Notch1 and Notch2 in developing and adult mouse brain.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1084181

Gamma -secretase inhibitors repress thymocyte development

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12101103

12 December 2020

inferred from PubMed ID database lookup

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12101103

12 December 2020

inferred from PubMed ID database lookup

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12101103

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/EMBO-REPORTS/KVF124

1 reference

29 July 2017

1 reference

29 July 2017

1 reference