Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells. (Q33747277)

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16 January 2020

title

Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells (English)

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16 January 2020

main subject

chronic myeloid leukemia

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1 reference

8

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16 January 2020

Tessa Holyoake

11

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16 January 2020

author name string

Nicholas B Heaney

1

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16 January 2020

Francesca Pellicano

2

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16 January 2020

Bin Zhang

3

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16 January 2020

Lisa Crawford

4

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16 January 2020

Su Chu

5

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16 January 2020

Syed M A Kazmi

6

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16 January 2020

Elaine K Allan

7

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16 January 2020

Alexandra E Irvine

9

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16 January 2020

Ravi Bhatia

10

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16 January 2020

language of work or name

English

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publication date

12 January 2010

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16 January 2020

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16 January 2020

volume

115

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issue

11

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16 January 2020

page(s)

2241-2250

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Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells

16 January 2020

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Adaphostin and bortezomib induce oxidative injury and apoptosis in imatinib mesylate-resistant hematopoietic cells expressing mutant forms of Bcr/Abl

21 June 2018

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21 June 2018

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21 June 2018

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Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors

21 June 2018

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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30 October 2018

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30 October 2018

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Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies

30 October 2018

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30 October 2018

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30 October 2018

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Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer

30 October 2018

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30 October 2018

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The proteasome inhibitor PS-341 inhibits growth and induces apoptosis in Bcr/Abl-positive cell lines sensitive and resistant to imatinib mesylate

30 October 2018

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30 October 2018

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30 October 2018

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30 October 2018

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30 October 2018

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30 October 2018

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BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells

30 October 2018

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12 December 2020

OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib

1 reference

12 December 2020

MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

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12 December 2020

Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34 CML cells

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12 December 2020

10.1182/BLOOD-2008-06-164582

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20068223 AND SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20068223 AND SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

20068223

1 reference