Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator. (Q33736617)

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22 March 2020

title

Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator (English)

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22 March 2020

5

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22 March 2020

author name string

Xinni Xie

1

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22 March 2020

Wei Chen

2

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22 March 2020

Ning Zhang

3

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22 March 2020

Mei Yuan

4

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22 March 2020

Zhibing Zheng

6

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22 March 2020

Hua Li

7

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22 March 2020

Lili Wang

8

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22 March 2020

publication date

30 May 2017

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Frontiers in Pharmacology

22 March 2020

published in

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22 March 2020

volume

8

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22 March 2020

page(s)

317

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The TZD insulin sensitizer clue provides a new route into diabetes drug discovery

22 March 2020

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Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice

21 June 2018

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Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

21 June 2018

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PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization

21 June 2018

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Selective peroxisome proliferator-activated receptor gamma (PPARgamma) modulation as a strategy for safer therapeutic PPARgamma activation

21 June 2018

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INT131: a selective modulator of PPAR gamma

21 June 2018

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P633H, a novel dual agonist at peroxisome proliferator-activated receptors alpha and gamma, with different anti-diabetic effects in db/db and KK-Ay mice.

21 June 2018

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INT-131, a PPARgamma agonist for the treatment of type 2 diabetes.

21 June 2018

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PRDM16 controls a brown fat/skeletal muscle switch

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The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities

21 June 2018

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Partial agonists activate PPARgamma using a helix 12 independent mechanism

21 June 2018

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Selective modulation of PPARγ activity can lower plasma glucose without typical thiazolidinedione side-effects in patients with Type 2 diabetes

21 January 2018

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21 January 2018

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21 January 2018

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28611668

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FPHAR.2017.00317

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28611668 AND SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28611668 AND SRC:MED&resulttype=core&format=json

22 March 2020

PubMed publication ID

28611668

1 reference