The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques (Q33730459)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19888196 AND SRC:MED&resulttype=core&format=json

11 February 2020

title

The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques (English)

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11 February 2020

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8

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James Wilson

10

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author name string

Lili Wang

1

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11 February 2020

Roberto Calcedo

2

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Huan Wang

3

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Peter Bell

4

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Rebecca Grant

5

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Luk H Vandenberghe

6

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Julio Sanmiguel

7

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Mark L Batshaw

9

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11 February 2020

publication date

3 November 2009

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11 February 2020

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volume

18

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issue

1

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page(s)

126-134

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describes a project that uses

11 February 2020

ImageJ

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.

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Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo

14 July 2018

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Cross-presentation of adeno-associated virus serotype 2 capsids activates cytotoxic T cells but does not render hepatocytes effective cytolytic targets

14 July 2018

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Pre-existing AAV capsid-specific CD8 T cells are unable to eliminate AAV-transduced hepatocytes

14 July 2018

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Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

14 July 2018

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Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer

14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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30 October 2018

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30 October 2018

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30 October 2018

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30 October 2018

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Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II.

30 October 2018

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Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

30 October 2018

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AAV2 vector harboring a liver-restricted promoter facilitates sustained expression of therapeutic levels of alpha-galactosidase A and the induction of immune tolerance in Fabry mice.

30 October 2018

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30 October 2018

Identifiers

DOI

10.1038/MT.2009.245

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19888196 AND SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19888196 AND SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

19888196

1 reference