Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling. (Q33726847)

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5 March 2020

title

Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling (English)

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5 March 2020

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3

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Zhan Yao

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Vanessa Rodrik-Outmezguine

5 March 2020

5

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author name string

Marie Will

1

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Alice Can Ran Qin

2

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Claudia Schneider

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Xiaodong Huang

7

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Prashant Monian

8

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Xuejun Jiang

9

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José Baselga

11

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Ningshu Liu

12

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Sarat Chandarlapaty

13

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Neal Rosen

14

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Elisa de Stanchina

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publication date

16 January 2014

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5 March 2020

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volume

4

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issue

3

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page(s)

334-347

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BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models

5 March 2020

cites work

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The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancer

21 June 2018

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Development of PI3K inhibitors: lessons learned from early clinical trials

21 June 2018

1 reference

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JAK2/STAT5 inhibition circumvents resistance to PI3K/mTOR blockade: a rationale for cotargeting these pathways in metastatic breast cancer

21 June 2018

1 reference

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Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

21 June 2018

1 reference

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mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling

21 June 2018

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First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors

21 June 2018

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Phosphoinositide 3-kinase regulates plasma membrane targeting of the Ras-specific exchange factor RasGRP1.

21 June 2018

1 reference

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PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

21 June 2018

1 reference

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

21 June 2018

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4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

21 June 2018

1 reference

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PTEN-deficient cancers depend on PIK3CB.

21 June 2018

1 reference

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

21 June 2018

1 reference

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Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling

21 June 2018

1 reference

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Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

21 June 2018

1 reference

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A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

21 June 2018

1 reference

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G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility

21 June 2018

1 reference

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

21 June 2018

1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 June 2018

1 reference

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BRAF mutation predicts sensitivity to MEK inhibition

21 June 2018

1 reference

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The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

21 June 2018

1 reference

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ERBB receptors and cancer: the complexity of targeted inhibitors

21 June 2018

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

21 June 2018

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High frequency of mutations of the PIK3CA gene in human cancers

21 June 2018

1 reference

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Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

21 June 2018

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A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

21 June 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 June 2018

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A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

21 June 2018

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Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

21 June 2018

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Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

21 June 2018

1 reference

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Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength

30 October 2018

1 reference

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10.1158/2159-8290.CD-13-0611

30 October 2018

Identifiers

DOI

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release_qg7p2d2o65f37m62adftmn4q2y

5 March 2020

Fatcat ID

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Fatcat

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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5 March 2020

PubMed publication ID

24436048

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