T-bet, a Th1 transcription factor regulates the expression of Tim-3. (Q33721890)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20049876 AND SRC:MED&resulttype=core&format=json

16 January 2020

title

T-bet, a Th1 transcription factor regulates the expression of Tim-3 (English)

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16 January 2020

2

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16 January 2020

7

Vijay K Kuchroo

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16 January 2020

6

Laurie H Glimcher

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16 January 2020

1

Ana C Anderson

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16 January 2020

author name string

Valerie Dardalhon

series ordinal

3

1 reference

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16 January 2020

David H Lee

series ordinal

4

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16 January 2020

Catherine A Sabatos-Peyton

series ordinal

5

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16 January 2020

language of work or name

English

0 references

publication date

1 March 2010

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European Journal of Immunology

16 January 2020

published in

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16 January 2020

volume

40

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16 January 2020

issue

3

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16 January 2020

page(s)

859-866

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TIM-3 is expressed on activated human CD4 T cells and regulates Th1 and Th17 cytokines

16 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4 and CD8 T cells

21 June 2018

1 reference

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Transcriptional regulatory networks in Th17 cell differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Lack of TIM-3 immunoregulation in multiple sclerosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

21 June 2018

TIM-3 in autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Dysregulated T cell expression of TIM3 in multiple sclerosis

21 June 2018

1 reference

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Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

21 June 2018

1 reference

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The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Interleukin 17-producing CD4 effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

T-bet is required for optimal proinflammatory CD4 T-cell trafficking.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Molecular mechanisms regulating Th1 immune responses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Selective eosinophil adhesion to fibroblast via IFN-gamma-induced galectin-9

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Lineage commitment in the immune system: the T helper lymphocyte grows up.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

A novel transcription factor, T-bet, directs Th1 lineage commitment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2837127

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20049876

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/EJI.200939842

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20049876 AND SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20049876 AND SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

20049876

1 reference