Potential drug targets: small GTPases that regulate leukocyte function (Q33720590)

28 July 2017

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title

Potential drug targets: small GTPases that regulate leukocyte function (English)

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28 July 2017

Benard V

1

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28 July 2017

Bokoch GM

series ordinal

2

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28 July 2017

Diebold BA

series ordinal

3

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28 July 2017

publication date

1 September 1999

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Trends in Pharmacological Sciences

28 July 2017

published in

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28 July 2017

volume

20

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28 July 2017

issue

9

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28 July 2017

page(s)

365-370

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Low-molecular-weight GTP-binding proteins and leukocyte signal transduction

28 July 2017

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Proteins regulating Ras and its relatives

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The human neutrophil respiratory burst oxidase

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Phospholipase D: a novel major player in signal transduction

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7 January 2021

Regulation of the phagocyte respiratory burst by small GTP-binding proteins

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7 January 2021

Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors.

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Protection from reoxygenation injury by inhibition of rac1.

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7 January 2021

Increased neutrophil respiratory burst in bcr-null mutants

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7 January 2021

Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity

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7 January 2021

Ras effector-homologue region on Rac regulates protein associations in the neutrophil respiratory burst oxidase complex

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7 January 2021

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

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7 January 2021

Mutational analysis of novel effector domains in Rac1 involved in the activation of nicotinamide adenine dinucleotide phosphate (reduced) oxidase

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7 January 2021

Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase

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7 January 2021

The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather than Rac1

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7 January 2021

Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox)

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7 January 2021

Signal transduction and actin filament organization

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7 January 2021

Rho GTPases and the Actin Cytoskeleton

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7 January 2021

A role for Cdc42 in macrophage chemotaxis

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7 January 2021

ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility

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7 January 2021

Role of Rho in chemoattractant-activated leukocyte adhesion through integrins

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7 January 2021

Regulation of Actin Polymerization in Cell-free Systems by GTPγS and Cdc42

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7 January 2021

Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes

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7 January 2021

Fc receptor-mediated phagocytosis requires CDC42 and Rac1.

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7 January 2021

Inhibition of Fc epsilon-RI-mediated activation of rat basophilic leukemia cells by Clostridium difficile toxin B (monoglucosyltransferase)

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Rho GTPases and signaling networks

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

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7 January 2021

Rho-family GTPases require the Arp2/3 complex to stimulate actin polymerization in Acanthamoeba extracts

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7 January 2021

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Rho Family GTPases Bind to Phosphoinositide Kinases

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.

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7 January 2021

Phosphatidylinositol 4,5-bisphosphate provides an alternative to guanine nucleotide exchange factors by stimulating the dissociation of GDP from Cdc42Hs

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

The Dbl family of oncogenes

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7 January 2021

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

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7 January 2021

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

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7 January 2021

GTPases: multifunctional molecular switches regulating vesicular traffic

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7 January 2021

Structure and function of ARF proteins: activators of cholera toxin and critical components of intracellular vesicular transport processes

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7 January 2021

ARF signaling: a potential role for phospholipase D in membrane traffic

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Apoptosis in leukocytes.

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7 January 2021

D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis

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7 January 2021

Apoptotic Membrane Blebbing Is Regulated by Myosin Light Chain Phosphorylation

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosisin Vitro

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Interaction between Cdc42Hs and RhoGDI Is Mediated through the Rho Insert Region

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules.

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

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7 January 2021

GTPase-activating proteins: helping hands to complement an active site

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Invasion of the nucleotide snatchers: structural insights into the mechanism of G protein GEFs

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

The structural basis of the activation of Ras by Sos

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Brefeldin A: the advantage of being uncompetitive

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

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7 January 2021

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Mapping of functional domains in p47(phox) involved in the activation of NADPH oxidase by "peptide walking".

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Regulation of NADPH oxidase activity by Rac GTPase activating protein(s).

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42.

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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https://api.crossref.org/works/10.1016/S0165-6147(99)01367-X

7 January 2021

10.1016/S0165-6147(99)01367-X

Identifiers

DOI

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28 July 2017

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