Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity (Q33714875)

28 July 2017

title

Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity (English)

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28 July 2017

1 reference

10

Bradley T Hyman

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28 July 2017

2

Karin M Danzer

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28 July 2017

Preeti Putcha

1

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28 July 2017

Lisa R Kranich

3

1 reference

28 July 2017

Anisa Scott

4

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28 July 2017

Melanie Silinski

5

1 reference

28 July 2017

Sarah Mabbett

6

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28 July 2017

Carol D Hicks

7

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28 July 2017

James M Veal

8

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28 July 2017

Paul M Steed

9

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28 July 2017

Pamela J McLean

11

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28 July 2017

language of work or name

English

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publication date

24 November 2009

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Journal of Pharmacology and Experimental Therapeutics

28 July 2017

published in

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28 July 2017

volume

332

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28 July 2017

issue

3

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28 July 2017

page(s)

849-857

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Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

28 July 2017

cites work

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SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

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21 June 2018

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CHIP targets toxic alpha-Synuclein oligomers for degradation

21 June 2018

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21 June 2018

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21 June 2018

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Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors

21 June 2018

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21 June 2018

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The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways

21 June 2018

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Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

21 June 2018

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Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro

21 June 2018

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Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 June 2018

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 June 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 June 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

21 June 2018

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Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

21 June 2018

1 reference

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TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation

21 June 2018

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 June 2018

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Geldanamycin provides posttreatment protection against glutamate-induced oxidative toxicity in a mouse hippocampal cell line

21 June 2018

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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 June 2018

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AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease

21 June 2018

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21 June 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 June 2018

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Different species of alpha-synuclein oligomers induce calcium influx and seeding.

21 June 2018

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A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity

30 October 2018

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Geldanamycin treatment reduces delayed CA1 damage in mouse hippocampal organotypic cultures subjected to oxygen glucose deprivation

30 October 2018

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Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo

30 October 2018

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Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

30 October 2018

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Evidence for a partially folded intermediate in alpha-synuclein fibril formation

30 October 2018

1 reference

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Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19934398

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Reaction of geldanamycin and C17-substituted analogues with glutathione: product identifications and pharmacological implications

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19934398

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A highly sensitive protein-protein interaction assay based on Gaussia luciferase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19934398

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/JPET.109.158436

1 reference

28 July 2017

1 reference

28 July 2017

1 reference