Prostanoid receptor EP2 as a therapeutic target (Q33711678)

28 July 2017

title

Prostanoid receptor EP2 as a therapeutic target (English)

1 reference

28 July 2017

1

Thota Ganesh

1 reference

28 July 2017

language of work or name

English

0 references

publication date

4 December 2013

1 reference

Journal of Medicinal Chemistry

28 July 2017

published in

1 reference

28 July 2017

volume

57

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28 July 2017

issue

11

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28 July 2017

page(s)

4454-4465

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Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists.

28 July 2017

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A Phase 2, Randomized, Dose-Response Trial of Taprenepag Isopropyl (PF-04217329) Versus Latanoprost 0.005% in Open-Angle Glaucoma and Ocular Hypertension

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In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist

21 June 2018

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Parkinson's Disease and Systemic Inflammation

21 June 2018

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Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development

21 June 2018

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Prostaglandin E(2) synthase inhibition as a therapeutic target

21 June 2018

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Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor

21 June 2018

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Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms.

21 June 2018

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Altered hippocampal long-term synaptic plasticity in mice deficient in the PGE2 EP2 receptor

21 June 2018

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The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

21 June 2018

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21 June 2018

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Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress

21 June 2018

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21 June 2018

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Prolonged microgliosis in the rhesus monkey central nervous system after traumatic brain injury

21 June 2018

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Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo

21 June 2018

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Stimulation of prostanoid IP and EP(2) receptors dilates retinal arterioles and increases retinal and choroidal blood flow in rats

21 June 2018

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Inflammatory bowel disease: cause and immunobiology

21 June 2018

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EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways

21 June 2018

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Prostaglandin E receptors

21 June 2018

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Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein

21 June 2018

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Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors

21 June 2018

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A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation

21 June 2018

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1,026 experimental treatments in acute stroke

21 June 2018

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Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis

21 June 2018

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The role of inflammation in CNS injury and disease

21 June 2018

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Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

21 June 2018

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Role of inflammation in neurodegenerative diseases

21 June 2018

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Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2.

21 June 2018

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Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity

21 June 2018

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Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation

21 June 2018

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Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells

21 June 2018

1 reference

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EP2 and EP4 prostanoid receptor signaling

21 June 2018

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Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer?

21 June 2018

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An EP2 receptor-selective prostaglandin E 2 agonist induces bone healing

21 June 2018

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Inflammatory processes in amyotrophic lateral sclerosis

21 June 2018

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Development of a highly selective EP2-receptor agonist. Part 2: identification of 16-hydroxy-17,17-trimethylene 9beta-chloro PGF derivatives

21 June 2018

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Cyclooxygenase-2: a therapeutic target

21 June 2018

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A double-masked, randomized clinical trial comparing latanoprost with unoprostone in patients with open-angle glaucoma or ocular hypertension

21 June 2018

1 reference

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Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration.

21 June 2018

1 reference

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Inflammation and Alzheimer's disease

21 June 2018

1 reference

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Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain

21 June 2018

1 reference

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The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

21 June 2018

1 reference

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Prostanoid receptors: structures, properties, and functions

21 June 2018

2 references

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21 June 2018

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Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)

30 October 2018

1 reference

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Cox-2-selective inhibitors: the new super aspirins

21 June 2018

1 reference

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

21 June 2018

1 reference

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Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis

21 June 2018

1 reference

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Renal toxicity of the nonsteroidal anti-inflammatory drugs

21 June 2018

1 reference

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Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Molecular mechanisms of membrane receptor desensitization.

21 June 2018

1 reference

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Toxicity of nonsteroidal anti-inflammatory drugs in the large intestine

21 June 2018

1 reference

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Characterization of prostanoid relaxant/inhibitory receptors (psi) using a highly selective agonist, TR4979.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Inflammation after trauma: microglial activation and traumatic brain injury

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

The PGE2 EP2 receptor and its selective activation are beneficial against ischemic stroke.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Inflammation and Parkinson's disease pathogenesis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

The prostanoid EP(2) receptor agonist ONO-AE1-259-01 protects against glutamate-induced neurotoxicity in rat retina.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Effects of the selective EP4 antagonist, CJ-023,423 on chronic inflammation and bone destruction in rat adjuvant-induced arthritis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

TNF-alpha/IFN-gamma-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and intracellular calcium signaling.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressiveness.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor development.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Microglial EP2 is critical to neurotoxicity from activated cerebral innate immunity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

COX-2-derived prostacyclin confers atheroprotection on female mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Epac: a new cAMP target and new avenues in cAMP research

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Prosurvival and antiapoptotic effects of PGE2 in radiation injury are mediated by EP2 receptor in intestine

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Design and synthesis of a highly selective EP2-receptor agonist

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Neuronal plasticity and survival in mood disorders.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4045661

The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis

30 October 2018

1 reference

12 December 2020

Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist

1 reference

12 December 2020

Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure

1 reference

12 December 2020

Rofecoxib, a specific inhibitor of cyclooxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: results of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip. Rofecoxib Phase III Protoco

1 reference

12 December 2020

Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis

1 reference

12 December 2020

Inflammatory processes in Alzheimer's disease

1 reference

12 December 2020

6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist

1 reference

12 December 2020

Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM401431X

1 reference

28 July 2017

1 reference

28 July 2017

1 reference