The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction (Q33702164)

28 July 2017

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title

The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction (English)

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28 July 2017

M L Lupher

1

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28 July 2017

N Rao

series ordinal

2

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28 July 2017

M J Eck

series ordinal

3

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28 July 2017

H Band

series ordinal

4

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28 July 2017

publication date

1 August 1999

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28 July 2017

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28 July 2017

volume

20

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28 July 2017

issue

8

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28 July 2017

page(s)

375-382

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T cell antigen receptor signal transduction

28 July 2017

cites work

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The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP?

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7 January 2021

Clathrin-coated vesicle formation and protein sorting: an integrated process

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7 January 2021

The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein

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7 January 2021

Molecules in focus: The c-Cbl oncoprotein

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7 January 2021

The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction.

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7 January 2021

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7 January 2021

Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development.

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7 January 2021

Cbl: complex formation and functional implications

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7 January 2021

p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase

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7 January 2021

Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes

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7 January 2021

Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors

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7 January 2021

Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells

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7 January 2021

Direct T cell activation by chimeric single chain Fv-Syk promotes Syk-Cbl association and Cbl phosphorylation

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7 January 2021

Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323

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7 January 2021

A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells

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7 January 2021

Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

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7 January 2021

Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein

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7 January 2021

Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

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7 January 2021

Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

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7 January 2021

Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

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7 January 2021

The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase

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7 January 2021

Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway

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7 January 2021

Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase association

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7 January 2021

Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.

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7 January 2021

The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

1 reference

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7 January 2021

Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

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7 January 2021

Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.

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7 January 2021

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

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7 January 2021

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

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7 January 2021

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

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7 January 2021

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1 reference

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7 January 2021

Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

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https://api.crossref.org/works/10.1016/S0167-5699(99)01484-X

7 January 2021

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

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https://api.crossref.org/works/10.1016/S0167-5699(99)01484-X

7 January 2021

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

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7 January 2021

Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation

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7 January 2021

syk protein tyrosine kinase regulates Fc receptor gamma-chain-mediated transport to lysosomes

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7 January 2021

Tyrosine-containing motif that transduces cell activation signals also determines internalization and antigen presentation via type III receptors for IgG

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7 January 2021

Activation-induced ubiquitination of the T cell antigen receptor

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7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

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7 January 2021

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

1 reference

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7 January 2021

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral.

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7 January 2021

Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

1 reference

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7 January 2021

Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice

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7 January 2021

Blocked Ras activation in anergic CD4 T cells

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7 January 2021

The role of phosphoinositide 3-kinase lipid products in cell function

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7 January 2021

Upstream-downstream: CD28 cosignaling pathways and T cell function

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7 January 2021

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

1 reference

https://api.crossref.org/works/10.1016/S0167-5699(99)01484-X

7 January 2021

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

1 reference

https://api.crossref.org/works/10.1016/S0167-5699(99)01484-X

7 January 2021

A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function

1 reference

https://api.crossref.org/works/10.1016/S0167-5699(99)01484-X

7 January 2021

Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

1 reference

https://api.crossref.org/works/10.1016/S0167-5699(99)01484-X

7 January 2021

Lymphocyte signalling: a coordinating role for Vav?

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https://api.crossref.org/works/10.1016/S0167-5699(99)01484-X

7 January 2021

Ex vivo evidence for asymmetric tyrosine phosphorylation of ZAP-70 on double-positive thymocytes in the positive selection process

1 reference

https://api.crossref.org/works/10.1016/S0167-5699(99)01484-X

7 January 2021

Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor

1 reference

https://api.crossref.org/works/10.1016/S0167-5699(99)01484-X

7 January 2021

10.1016/S0167-5699(99)01484-X

Identifiers

DOI

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28 July 2017

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