Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis (Q33697376)

28 July 2017

title

Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis (English)

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28 July 2017

6

Dan R Littman

1 reference

28 July 2017

Bindya Jacob

1

1 reference

28 July 2017

Motomi Osato

2

1 reference

28 July 2017

Namiko Yamashita

3

1 reference

28 July 2017

Chelsia Qiuxia Wang

4

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28 July 2017

Ichiro Taniuchi

5

1 reference

28 July 2017

Norio Asou

7

1 reference

28 July 2017

Yoshiaki Ito

8

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28 July 2017

language of work or name

English

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publication date

14 December 2009

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28 July 2017

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28 July 2017

volume

115

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28 July 2017

issue

8

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28 July 2017

page(s)

1610-1620

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AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis.

28 July 2017

cites work

1 reference

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RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes

21 June 2018

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Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

21 June 2018

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Targeting of CD44 eradicates human acute myeloid leukemic stem cells

21 June 2018

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Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

21 June 2018

1 reference

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Stem cells and their niches

21 June 2018

1 reference

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Bone-marrow haematopoietic-stem-cell niches

21 June 2018

1 reference

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The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1

21 June 2018

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Haploinsufficiency of Runx1/AML1 promotes myeloid features and leukaemogenesis in BXH2 mice.

21 June 2018

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AML1 deletion in adult mice causes splenomegaly and lymphomas.

21 June 2018

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Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment

21 June 2018

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Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia

21 June 2018

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Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis

21 June 2018

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Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression

21 June 2018

1 reference

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Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice.

21 June 2018

1 reference

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Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.

21 June 2018

1 reference

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Retroviral insertional mutagenesis identifies oncogene cooperation

21 June 2018

1 reference

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Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia

21 June 2018

1 reference

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CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice

21 June 2018

1 reference

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

21 June 2018

1 reference

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RTCGD: retroviral tagged cancer gene database

21 June 2018

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Core-binding factors in haematopoiesis and leukaemia

21 June 2018

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AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 June 2018

1 reference

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Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

21 June 2018

1 reference

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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 June 2018

1 reference

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The AML1/ETO fusion protein activates transcription of BCL-2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830765

Retroviral insertional mutagenesis as a strategy to identify cancer genes

21 June 2018

1 reference

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 June 2018

1 reference

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

21 June 2018

1 reference

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Inducible gene targeting in mice

21 June 2018

1 reference

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Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

21 June 2018

1 reference

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High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder.

21 June 2018

1 reference

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Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830765

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830765

Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830765

The t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830765

Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830765

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830765

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

30 October 2018

1 reference

12 December 2020

Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult

1 reference

12 December 2020

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias

1 reference

12 December 2020

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

1 reference

12 December 2020

10.1182/BLOOD-2009-07-232249

Identifiers

DOI

1 reference

28 July 2017

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28 July 2017

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