Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels (Q33695967)

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English	Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 July 2017

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

1 reference

based on heuristic

inferred from title

lymphoblastic leukemia

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based on heuristic

inferred from title

B-cell acute lymphoblastic leukemia

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based on heuristic

inferred from title

Ana Margarida Gomes

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24561792 AND SRC:MED&resulttype=core&format=json

7 June 2020

Leila R Martins

6

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7 June 2020

7

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7 June 2020

João F Lacerda

10

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7 June 2020

João T. Barata

11

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7 June 2020

author name string

Maria V D Soares

2

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7 June 2020

Patrícia Ribeiro

3

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7 June 2020

Joana Caldas

4

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7 June 2020

Vanda Póvoa

5

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7 June 2020

Ana Serra-Caetano

8

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7 June 2020

Aida B de Sousa

9

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7 June 2020

publication date

21 February 2014

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28 July 2017

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7 June 2020

99

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7 June 2020

6

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7 June 2020

1062-1068

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7 June 2020

Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia

1 reference

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21 June 2018

Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia

1 reference

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21 June 2018

Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia

1 reference

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21 June 2018

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia

1 reference

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Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways

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Antileukaemia effect of rapamycin alone or in combination with daunorubicin on Ph acute lymphoblastic leukaemia cell line

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Biology, risk stratification, and therapy of pediatric acute leukemias: an update

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CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

1 reference

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The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival

1 reference

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Novel Targets for Treatment of Adult Acute Lymphocytic Leukemia

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Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.

1 reference

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21 June 2018

STAT5 in B cell development and leukemia

1 reference

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21 June 2018

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors

1 reference

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21 June 2018

Addiction to protein kinase CK2: a common denominator of diverse cancer cells?

1 reference

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21 June 2018

Protein kinase CK2 in health and disease: CK2: a key player in cancer biology

1 reference

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21 June 2018

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

1 reference

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21 June 2018

Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study

1 reference

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21 June 2018

Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.

1 reference

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21 June 2018

The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL

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Single cell profiling of potentiated phospho-protein networks in cancer cells.

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TSC2 mediates cellular energy response to control cell growth and survival

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21 June 2018

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

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21 June 2018

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

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Phosphorylation of the PTEN tail regulates protein stability and function

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Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

1 reference

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21 June 2018

Inactivation of PTEN increases ABCG2 expression and the side population through the PI3K/Akt pathway in adult acute leukemia

1 reference

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30 October 2018

Src, Akt, NF-κB, BCL-2 and c-IAP1 may be involved in an anti-apoptotic effect in patients with BCR-ABL positive and BCR-ABL negative acute lymphoblastic leukemia.

1 reference

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30 October 2018

Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells

1 reference

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30 October 2018

Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia

1 reference

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1 reference

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Identifiers

10.3324/HAEMATOL.2013.096438

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24561792 AND SRC:MED&resulttype=core&format=json

7 June 2020

PMC publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24561792 AND SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24561792 AND SRC:MED&resulttype=core&format=json

7 June 2020

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