Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity. (Q33688908)

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English	Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.	scientific article

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12 March 2020

Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity (English)

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12 March 2020

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Vincent W. Keng

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David A Largaespada

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David A Largaespada

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Adrienne L Watson

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Leah K Anderson

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Andrew D Greeley

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Eric P Rahrmann

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Amanda L Halfond

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Natasha M Powell

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Margaret H Collins

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Tilat Rizvi

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Christopher L Moertel

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Nancy Ratner

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12 March 2020

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12 March 2020

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12 March 2020

1502-1514

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11 June 2022

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Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis

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FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies

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Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance

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Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.

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PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.

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21 June 2018

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Current status of sporadic and neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.

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Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients

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Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients

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Pediatric Malignant Peripheral Nerve Sheath Tumor: The Italian and German Soft Tissue Sarcoma Cooperative Group

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10.18632/ONCOTARGET.1609

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