Minireview: latest perspectives on antiinflammatory actions of glucocorticoids (Q33670499)

28 July 2017

1 reference

title

Minireview: latest perspectives on antiinflammatory actions of glucocorticoids (English)

1 reference

28 July 2017

1

Karolien De Bosscher

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author name string

Guy Haegeman

series ordinal

2

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28 July 2017

publication date

18 December 2008

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28 July 2017

published in

Molecular Endocrinology

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28 July 2017

volume

23

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28 July 2017

issue

3

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28 July 2017

page(s)

281-291

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TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme

28 July 2017

cites work

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A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis

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Transrepression function of the glucocorticoid receptor regulates eyelid development and keratinocyte proliferation but is not sufficient to prevent skin chronic inflammation

21 June 2018

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Glucocorticoid/glucocorticoid receptor inhibition of surfactant protein-A (SP-A) gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A promoter

21 June 2018

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21 June 2018

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Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation

21 June 2018

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Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index.

21 June 2018

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Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists

21 June 2018

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Separating transrepression and transactivation: a distressing divorce for the glucocorticoid receptor?

21 June 2018

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Glucocorticoids and the innate immune system: crosstalk with the toll-like receptor signaling network.

21 June 2018

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Anti-inflammatory functions of glucocorticoid-induced genes

21 June 2018

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Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor

21 June 2018

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Steroid receptor phosphorylation: a key modulator of multiple receptor functions

21 June 2018

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Impact of post-translational modifications of proteins on the inflammatory process

21 June 2018

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A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90.

21 June 2018

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Glucocorticoids in the regulation of transcription factors that control cytokine synthesis

21 June 2018

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Coregulators: transducing signal from transcription to alternative splicing.

21 June 2018

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Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression

21 June 2018

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The ligand binding domain controls glucocorticoid receptor dynamics independent of ligand release.

21 June 2018

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The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction

21 June 2018

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DAX1: Increasing complexity in the roles of this novel nuclear receptor

21 June 2018

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The anti-inflammatory effect of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cells

21 June 2018

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Annexin 1, glucocorticoids, and the neuroendocrine-immune interface

21 June 2018

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The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438.

21 June 2018

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Glucocorticoid-induced leucine zipper (GILZ)/NF-kappaB interaction: role of GILZ homo-dimerization and C-terminal domain.

21 June 2018

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Cross-talk between nuclear receptors and nuclear factor kappaB.

21 June 2018

1 reference

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Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification.

21 June 2018

1 reference

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Analysis of the dissociated steroid RU24858 does not exclude a role for inducible genes in the anti-inflammatory actions of glucocorticoids

21 June 2018

1 reference

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Tissue specific glucocorticoid receptor expression, a role for alternative first exon usage?

21 June 2018

1 reference

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Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

21 June 2018

1 reference

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The glucocorticoid RU24858 does not distinguish between transrepression and transactivation in primary human eosinophils.

21 June 2018

1 reference

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Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ.

21 June 2018

1 reference

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Glucocorticoid receptor isoforms generate transcription specificity.

21 June 2018

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MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis

21 June 2018

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Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity

21 June 2018

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Corticosteroids: the drugs to beat

21 June 2018

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MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock

21 June 2018

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Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression

21 June 2018

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New and improved glucocorticoid receptor ligands

21 June 2018

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Identification of novel steroid target genes through the combination of bioinformatics and functional analysis of hormone response elements

21 June 2018

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A fully dissociated compound of plant origin for inflammatory gene repression

21 June 2018

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Antiinflammatory action of glucocorticoids--new mechanisms for old drugs

21 June 2018

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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

21 June 2018

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A pharmacological approach to enhancing the therapeutic index of corticosteroids in airway inflammatory disease

21 June 2018

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The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.

21 June 2018

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Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes.

21 June 2018

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Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment

21 June 2018

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Identification of endogenous glucocorticoid repressed genes differentially regulated by a glucocorticoid receptor mutant able to separate between nuclear factor-kappaB and activator protein-1 repression

21 June 2018

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Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.

21 June 2018

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Corticosteroid resistance in rheumatoid arthritis: molecular and cellular perspectives

21 June 2018

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Glucocorticoids and tumor necrosis factor alpha cooperatively regulate toll-like receptor 2 gene expression.

21 June 2018

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Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation

21 June 2018

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The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

21 June 2018

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The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression

21 June 2018

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Nongenomic steroid action: controversies, questions, and answers

21 June 2018

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MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

21 June 2018

1 reference

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Molecular mechanisms of glucocorticoid action and resistance

21 June 2018

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Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

21 June 2018

1 reference

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A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects

21 June 2018

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Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 June 2018

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Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts

21 June 2018

1 reference

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Mechanisms involved in the side effects of glucocorticoids

21 June 2018

1 reference

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Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1

21 June 2018

1 reference

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Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition

21 June 2018

1 reference

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Glucocorticoid-stimulated lung epithelial Na( ) transport is associated with regulated ENaC and sgk1 expression

21 June 2018

1 reference

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MAPK-regulated transcription: a continuously variable gene switch?

21 June 2018

1 reference

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Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin

21 June 2018

1 reference

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Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones

21 June 2018

1 reference

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Molecular identification and characterization of a and b forms of the glucocorticoid receptor.

21 June 2018

1 reference

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Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ.

21 June 2018

1 reference

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Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity

21 June 2018

1 reference

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Molecular genetic dissection of glucocorticoid receptor function in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 gene

21 June 2018

1 reference

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Molecular mechanisms of glucocorticoid action: what is important?

21 June 2018

1 reference

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The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor

21 June 2018

1 reference

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Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

21 June 2018

1 reference

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DNA binding of the glucocorticoid receptor is not essential for survival

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Synthetic Glucocorticoids That Dissociate Transactivation and AP-1 Transrepression Exhibit Antiinflammatory Activityin Vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Role of c-jun induction in the glucocorticoid-evoked apoptotic pathway in human leukemic lymphoblasts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Activation of the mitogen-activated protein kinase cascade is suppressed by low concentrations of dexamethasone in mast cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Coordinate regulation of glucocorticoid receptor and c-jun gene expression is cell type-specific and exhibits differential hormonal sensitivity for down- and up-regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Cross talk of signaling pathways in the regulation of the glucocorticoid receptor function

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

LGD-5552, an antiinflammatory glucocorticoid receptor ligand with reduced side effects, in vivo

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

MAPK phosphatase-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Essential role of MAPK phosphatase-1 in the negative control of innate immune responses

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutants

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Cell type-dependent divergence of transactivation by glucocorticoid receptor ligand

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappaB-dependent mechanism

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Transrepression of c-jun gene expression by the glucocorticoid receptor requires both AP-1 sites in the c-jun promoter

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5428155

Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis

30 October 2018

1 reference

12 December 2020

An active nuclear retention signal in the glucocorticoid receptor functions as a strong inducer of transcriptional activation

1 reference

12 December 2020

Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation

1 reference

12 December 2020

Superior nuclear receptor selectivity and therapeutic index of methylprednisolone aceponate versus mometasone furoate

1 reference

12 December 2020

GILZ, a glucocorticoid hormone induced gene, modulates T lymphocytes activation and death through interaction with NF-kB

1 reference

12 December 2020

Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators

1 reference

12 December 2020

Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein

1 reference

12 December 2020

Glucocorticoid regulation of cyclin D3 gene transcription and mRNA stability in lymphoid cells

1 reference

12 December 2020

Mapping of glucocorticoid receptor DNA binding domain surfaces contributing to transrepression of NF-kappa B and induction of apoptosis

1 reference

12 December 2020

Update on glucocorticoid action and resistance

1 reference

12 December 2020

Identifiers

DOI

10.1210/ME.2008-0283

1 reference

28 July 2017

1 reference

28 July 2017

1 reference