Lead optimization studies of cinnamic amide EP2 antagonists (Q33654575)

24773616

28 July 2017

title

Lead optimization studies of cinnamic amide EP2 antagonists (English)

1 reference

28 July 2017

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24773616 AND SRC:MED&resulttype=core&format=json

1 June 2020

Raymond Dingledine

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24773616 AND SRC:MED&resulttype=core&format=json

1 June 2020

1

Thota Ganesh

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24773616 AND SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Myung-Soon Yang

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24773616 AND SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

English

0 references

publication date

5 May 2014

1 reference

24773616

Journal of Medicinal Chemistry

28 July 2017

published in

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1 June 2020

volume

57

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1 June 2020

issue

10

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1 June 2020

page(s)

4173-4184

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Prostanoid receptor EP2 as a therapeutic target

1 June 2020

cites work

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Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

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Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.

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In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist

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Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms.

21 June 2018

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The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

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21 June 2018

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EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways

21 June 2018

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21 June 2018

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Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein

21 June 2018

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21 June 2018

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Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis

21 June 2018

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The role of inflammation in CNS injury and disease

21 June 2018

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Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

21 June 2018

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21 June 2018

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Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2.

21 June 2018

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Microglia lacking E Prostanoid Receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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30 October 2018

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

21 June 2018

1 reference

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Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

21 June 2018

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21 June 2018

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Inflammation after trauma: microglial activation and traumatic brain injury

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032197

Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032197

The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032197

Inflammation and Parkinson's disease pathogenesis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032197

Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4032197

Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism

30 October 2018

1 reference

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Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus

30 October 2018

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Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor development.

30 October 2018

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Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.

30 October 2018

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Effect of naproxen, a non-selective cyclo-oxygenase inhibitor, on pentylenetetrazol-induced kindling in mice

30 October 2018

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COX-2-derived prostacyclin confers atheroprotection on female mice

30 October 2018

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Epac: a new cAMP target and new avenues in cAMP research

30 October 2018

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Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

30 October 2018

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Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent

30 October 2018

1 reference

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Prostaglandin E2 exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis

30 October 2018

1 reference

12 December 2020

Rofecoxib, a specific inhibitor of cyclooxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: results of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip. Rofecoxib Phase III Protoco

1 reference

12 December 2020

Inflammatory processes in Alzheimer's disease

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12 December 2020

Cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction and cerebrovascular accident

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12 December 2020

Identifiers

DOI

10.1021/JM5000672

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24773616 AND SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24773616 AND SRC:MED&resulttype=core&format=json

1 June 2020

24773616

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24773616 AND SRC:MED&resulttype=core&format=json