Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG. (Q33640513)

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1 January 2020

title

Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG (English)

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3

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author name string

Michael T Morgan

series ordinal

1

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1 January 2020

Matthew T Bennett

series ordinal

2

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language of work or name

English

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publication date

29 June 2007

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Journal of Biological Chemistry

1 January 2020

published in

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volume

282

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issue

38

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1 January 2020

page(s)

27578-27586

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5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity

1 January 2020

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Molecular mechanisms of sister-chromatid exchange

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Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability

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21 June 2018

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Adenine release is fast in MutY-catalyzed hydrolysis of G:A and 8-Oxo-G:A DNA mismatches

21 June 2018

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Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in human inflammatory tissue

21 June 2018

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The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine

21 June 2018

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Uracil in DNA--occurrence, consequences and repair

21 June 2018

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hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

21 June 2018

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Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover

21 June 2018

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21 June 2018

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Characterization of the substrate specificity of a human 5-hydroxymethyluracil glycosylase activity

21 June 2018

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The role of DNA methylation in mammalian epigenetics

21 June 2018

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Bromination of deoxycytidine by eosinophil peroxidase: a mechanism for mutagenesis by oxidative damage of nucleotide precursors

21 June 2018

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Production of brominating intermediates by myeloperoxidase. A transhalogenation pathway for generating mutagenic nucleobases during inflammation

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

21 June 2018

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21 June 2018

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21 June 2018

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3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase

21 June 2018

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Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions

21 June 2018

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Multiple mutations in human cancers

21 June 2018

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Instability and decay of the primary structure of DNA

21 June 2018

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The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells

21 June 2018

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Mechanisms of excision of 5-fluorouracil by uracil DNA glycosylase in normal human cells.

21 June 2018

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Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells

21 June 2018

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The genetic toxicology of 5-fluoropyrimidines and 5-chlorouracil

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

21 June 2018

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Kinetics of the action of thymine DNA glycosylase

21 January 2018

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Base analog and neighboring base effects on substrate specificity of recombinant human G:T mismatch-specific thymine DNA-glycosylase.

21 January 2018

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5-Chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation. A gas chromatography-mass spectrometry assay

21 January 2018

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Mismatch uracil glycosylase from Escherichia coli: a general mismatch or a specific DNA glycosylase?

21 January 2018

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Mutational analysis of the base-flipping mechanism of uracil DNA glycosylase

21 January 2018

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The eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-bromouracil, a mutagenic thymine analogue

21 January 2018

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The optimal design of batteries of short-term tests for detecting carcinogens

21 January 2018

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Ionization of bromouracil and fluorouracil stimulates base mispairing frequencies with guanine

21 January 2018

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Sister-chromatid exchanges and gene mutations are induced by the replication of 5-bromo- and 5-chloro-deoxyuridine substituted DNA.

30 October 2018

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Hypochlorous Acid-Induced Base Modifications in Isolated Calf Thymus DNA

30 October 2018

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Uncatalyzed hydrolysis of deoxyuridine, thymidine, and 5-bromodeoxyuridine

21 January 2018

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12 December 2020

Acidic hydrolysis of deoxycytidine and deoxyuridine derivatives. The general mechanism of deoxyribonucleoside hydrolysis

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12 December 2020

SCE induction is proportional to substitution in DNA for thymidine by CldU and BrdU

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12 December 2020

The biochemical basis of 5-bromouracil-induced mutagenesis. Heteroduplex base mispairs involving bromouracil in G x C----A x T and A x T----G x C mutational pathways

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Equilibrium between a wobble and ionized base pair formed between fluorouracil and guanine in DNA as studied by proton and fluorine NMR

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Identifiers

DOI

10.1074/JBC.M704253200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17602166 AND SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17602166 AND SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

17602166

1 reference