Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans (Q33599854)

28 July 2017

1 reference

title

Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans (English)

1 reference

28 July 2017

0 references

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Cook JC

1

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28 July 2017

Klinefelter GR

2

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28 July 2017

Hardisty JF

3

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28 July 2017

Sharpe RM

4

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28 July 2017

Foster PM

5

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28 July 2017

language of work or name

English

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publication date

1 March 1999

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Critical Reviews in Toxicology

28 July 2017

published in

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28 July 2017

volume

29

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28 July 2017

issue

2

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28 July 2017

page(s)

169-261

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Characterization of estrogen binding in the developing rat testis ontogeny of the testicular cytoplasmic estrogen receptor

28 July 2017

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Estrogen Dependence of a Gonadotropin-induced Steroidogenic Lesion in Rat Testicular Leydig Cells

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Carcinogenicity of nitrosamines and methanesulphonate esters given intraperitoneally, in RF mice.

21 January 2018

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Leydig cell hyperplasia and adenoma formation: mechanisms and relevance to humans

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1,1,1,2-Tetrafluoroethane: repeat exposure inhalation toxicity in the rat, developmental toxicity in the rabbit, and genotoxicity in vitro and in vivo

21 January 2018

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Induction of Leydig cell adenomas by ammonium perfluorooctanoate: a possible endocrine-related mechanism

21 January 2018

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Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats

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Is cyclic AMP an obligatory second messenger for luteinizing hormone?

21 January 2018

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Transiently elevated levels of c-fos and c-myc oncogene messenger ribonucleic acids in cultured murine Leydig tumor cells after addition of human chorionic gonadotropin

21 January 2018

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Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations

21 January 2018

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Effects of a dietary load of acid or base on changes induced by lactose in rats

21 January 2018

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Oestradiol-17 beta and testosterone in rat testis tissue: effect of gonadotrophins, localization and production in vitro

21 January 2018

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Metachronous germ cell and Leydig cell tumors of the testis. Do testicular germ cell tumors and Leydig cell tumors share common etiologic factors?

21 January 2018

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Investigations of the carcinogenicity of the LH-RH analog buserelin (HOE 766) in rats using the subcutaneous route of administration

21 January 2018

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Alterations in mitogenic and steroidogenic activities in rat testicular interstitial fluid after administration of ethane dimethane sulphonate

21 January 2018

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Endocrine regulation and communicating functions of the Leydig cell

21 January 2018

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The binding properties of pyrethroids to human skin fibroblast androgen receptors and to sex hormone binding globulin

21 January 2018

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Glucocorticoids and hCG sensitivity of rat testicular Leydig cell.

21 January 2018

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Effect of transforming growth factor-beta on human chorionic gonadotropin induced testosterone production by cultured rat testicular cells

21 January 2018

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21 January 2018

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EVIDENCE OF TESTICULAR ACTIVITY IN EARLY INFANCY

21 January 2018

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Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease

21 January 2018

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Diazepam binding inhibitor is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis: action via peripheral-type benzodiazepine receptor and independent mechanisms

21 January 2018

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Sertoli cells are the site of interleukin-1α synthesis in rat testis

21 January 2018

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Comparative chronic toxicity of three oral estrogens in rats

21 January 2018

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Long term tumorigenicity of a single application of indomethacin or Amuno in adolescent and in adult male Sprague Dawley rats

21 January 2018

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Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat.

21 January 2018

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Germinal Cell Aplasia: Response of Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone to LH/FSH-Releasing Hormone with Histopathologic Correlation

21 January 2018

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Developmental changes in in vitro testosterone production by dispersed Leydig cells during fetal life in rats

21 January 2018

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The role of cytokines in the regulation of Leydig cell P450c17 gene expression

21 January 2018

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The mature form of interleukin-1 alpha is constitutively expressed in immature male germ cells from rat

21 January 2018

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Quantification of Leydig cells and measurement of Leydig-cell size following administration of human chorionic gonadotrophin to normal men

21 January 2018

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Thyroid follicular cell carcinogenesis

21 January 2018

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Toxicology and epidemiology of 1,3-butadiene

21 January 2018

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Distribution and fine structure of the lymphatic system in the human testis

21 January 2018

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In vivo conversion of dehydroisoandrosterone to plasma androstenedione and testosterone in man.

21 January 2018

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The affinity of procymidone to androgen receptor in rats and mice

21 January 2018

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Lack of Influence of Hypophysectomy on Estrogen-Induced DNA Synthesis in Leydig Cells of BALB/c Mice2

21 January 2018

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Leydig cell neoplasia in a patient with Reifenstein syndrome

21 January 2018

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Pathological and morphometric assessment of testicular parameters in patients with metastatic prostate cancer following treatment with either the antiandrogen Casodex (ZM176,334) or bilateral orchidectomy.

21 January 2018

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The Effect of the Steroidal Androgen Receptor Antagonist, Win 49,596, on the Prostate and Testis of Beagle Dogs

21 January 2018

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Reversal of long-term LH deprivation on testosterone secretion and Leydig cell volume, number and proliferation in adult rats

21 January 2018

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Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist

21 January 2018

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Alterations of the Fine Structure and Androgen Secretion of the Interstitial Cells in the Experimentally Cryptorchid Rat Testis

21 January 2018

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Growth factor requirements for DNA synthesis by Leydig cells from the immature rat.

21 January 2018

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Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty

21 January 2018

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Regulation of Leydig cell function in primary culture by inhibin and activin

21 January 2018

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Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis

21 January 2018

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The direct effect of hepatic peroxisome proliferators on rat Leydig cell function in vitro

21 January 2018

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Effect of the peroxisome proliferator, ammonium perfluorooctanoate (C8), on hepatic aromatase activity in adult male Crl:CD BR (CD) rats

21 January 2018

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21 January 2018

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21 January 2018

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The effects of chorionic gonadotropin in adult men: increased estrogen and 17-ketosteroid excretion, gynecomastia, leydig cell stimulation and semi-niferous tubule damage

21 January 2018

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21 January 2018

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21 January 2018

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Evaluation of the possible direct effects of gonadotrophin-releasing hormone analogues on the monkey (Macaca mulatta) testis

21 January 2018

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21 January 2018

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Neoplasms and related proliferative lesions in control Sprague-Dawley rats from carcinogenicity studies. Historical data and diagnostic considerations

21 January 2018

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Evaluation of the genotoxicity potential and chronic inhalation toxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b).

21 January 2018

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Proliferative lesions in the male reproductive system of F344 rats and B6C3F1 mice: incidence and classification.

21 January 2018

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Comparative aspects of 11 beta-hydroxysteroid dehydrogenase. Testicular 11 beta-hydroxysteroid dehydrogenase: development of a model for the mediation of Leydig cell function by corticosteroids

21 January 2018

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Interleukin-1 alpha-induced changes in androgen and cyclic adenosine 3',5'-monophosphate release in adult rat Leydig cells in culture

21 January 2018

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Binding of oestradiol by the nuclear fraction of rat testis interstitial tissue

21 January 2018

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Testicular Maturation in the Rat. In vivo Effect of Gonadotropins on Steroidogenic Enzymes in the Hypophysectomized Immature Rat

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Basic fibroblast growth factor inhibits delta 5-3 beta-hydroxysteroid dehydrogenase-isomerase activity in cultured immature Leydig cells

21 January 2018

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Fibroblast growth factor inhibits 5 alpha-reductase activity in cultured immature Leydig cells

21 January 2018

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Control of production of insulin-like growth factor I by pig Leydig and Sertoli cells cultured alone or together. Cell-cell interactions

21 January 2018

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Effects of FSH on Leydig cell morphology and function in the hypogonadal mouse

21 January 2018

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Sertoli cell-secreted protein(s) stimulates DNA synthesis in purified rat Leydig cells in vitro

21 January 2018

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Inhalation toxicity studies with 1,3-butadiene. 3. Two year toxicity/carcinogenicity study in rats

21 January 2018

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Chronic toxicity and carcinogenicity evaluation of fenvalerate in rats.

21 January 2018

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Hormonal regulation of steroidogenic enzyme gene expression in Leydig cells

21 January 2018

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The inhibitory GTP-binding protein (Gi) occurs in rat Leydig cells and is differentially modified by lutropin and 12-O-tetradecanoylphorbol 13-acetate

21 January 2018

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A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man

21 January 2018

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Evaluation of the evidence that tobacco-specific nitrosamines (TSNA) cause cancer in humans

21 January 2018

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Evaluation of the carcinogenic potential of pesticides. 4. Chloroalkylthiodicarboximide compounds with fungicidal activity

21 January 2018

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Interstitial cell carcinomas of the testis in Balb/C male mice ingesting methoxychlor

21 January 2018

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Evidence for leydig cell dysfunction in rats with seminiferous tubule damage

21 January 2018

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Effect of cryptorchidism on steroidogenic and mitogenic activities in rat testicular interstitial fluid

21 January 2018

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CADMIUM NEOPLASIA: TESTICULAR ATROPHY AND LEYDIG CELL HYPERPLASIA AND NEOPLASIA IN RATS AND MICE FOLLOWING THE SUBCUTANEOUS INJECTION OF CADMIUM SALTS

21 January 2018

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Gonadotropin-Independent Familial Sexual Precocity with Premature Leydig and Germinal Cell Maturation (Familial Testotoxicosis): Effects of a Potent Luteinizing Hormone-Releasing Factor Agonist and Medroxyprogesterone Acetate Therapy in Four Cases*

21 January 2018

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Methyl tertiary butyl ether (MTBE)--evaluation of MTBE carcinogenicity studies

21 January 2018

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Prolactin desensitizes the prostaglandin E1-dependent adenylyl cyclase in the rat prostate gland

21 January 2018

1 reference

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Experimental Induction of Hepatomas, Mammary Tumors, and Other Tumors With Metronidazole in Noninbred Sas:MRC(WI)BR Rats2

21 January 2018

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Effect of seminiferous tubule size on hCG-induced regeneration of peritubular Leydig cells in hypophysectomized, EDS-treated rats

21 January 2018

1 reference

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Testosterone Secretion in Cryptorchid and Intact Bulls Injected with Gonadotropin-Releasing Hormone and Luteinizing Hormone

21 January 2018

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Long-term toxicologic and tumorigenesis studies on an oral contraceptive agent in albino rats

21 January 2018

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Testicular leydig cell hyperplasia as a cause of familial sexual precocity

21 January 2018

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Cell-cell interactions in the control of spermatogenesis as studied using Leydig cell destruction and testosterone replacement

21 January 2018

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A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

21 January 2018

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https://api.crossref.org/works/10.1080/10408449991349203

Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues

21 January 2018

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https://api.crossref.org/works/10.1080/10408449991349203

Isolation of human Leydig cells which are highly responsive to human chorionic gonadotropin

21 January 2018

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The effects of histamine H2 receptor antagonists on androgen action in vivo and dihydrotestosterone binding to the rat prostate androgen receptor in vitro

21 January 2018

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Transforming growth factor-alpha gene expression and action in the seminiferous tubule: peritubular cell-Sertoli cell interactions

21 January 2018

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https://api.crossref.org/works/10.1080/10408449991349203

Cell-cell interactions in the testis

21 January 2018

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https://api.crossref.org/works/10.1080/10408449991349203

Partial characterization of a somatomedin-like peptide from the medium of cultured rat Sertoli cells

21 January 2018

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A rat Sertoli cell factor similar to basic fibroblast growth factor increases c-fos messenger ribonucleic acid in cultured Sertoli cells

21 January 2018

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Production and secretion of an interleukin-1-like factor is stage-dependent and correlates with spermatogonial DNA synthesis in the rat seminiferous epithelium

21 January 2018

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Free and serum testosterone levels in 276 males: a comparative study of rheumatoid arthritis, ankylosing spondylitis and healthy controls

21 January 2018

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Effects of FSH and testosterone on intratesticular insulin-like growth factor-I and specific germ cell populations in rats treated with gonadotrophin-releasing hormone antagonist.

21 January 2018

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A StAR search: implications in controlling steroidgenesis

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Chemically induced proliferation of peroxisomes: implications for risk assessment

21 January 2018

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Residual bodies activate Sertoli cell interleukin-1 alpha (IL-1 alpha) release, which triggers IL-6 production by an autocrine mechanism, through the lipoxygenase pathway

21 January 2018

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A synergistic effect of nitrosodimethylamine on sterigmatocystin carcinogenesis in rats

21 January 2018

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Effects of chronic nicotine administration and age in male Fischer-344 rats

21 January 2018

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Safety assessment of HCFC-141b: use as a blowing agent for insulation in building construction and refrigeration

21 January 2018

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Isolation and partial characterization of basic fibroblast growth factor from bovine testis

21 January 2018

1 reference

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Milk consumption and cancer incidence: a Norwegian prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Regulation of testicular function by insulin and transforming growth factor-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Interleukin-1 stimulates steroidogenesis in cultured rat Leydig cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Stimulatory effects of recombinant follicle-stimulating hormone on Leydig cell function and spermatogenesis in immature hypophysectomized rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

The effects of continuous testosterone exposure on spontaneous and cadmium-induced tumors in the male Fischer (F344/NCr) rat: loss of testicular response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Carcinogenicity of oral cadmium in the male Wistar (WF/NCr) rat: effect of chronic dietary zinc deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Toxicological principles of metal carcinogenesis with special emphasis on cadmium

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Mice Are Insensitive to the Antitesticular Effects of Luteinizing Hormone-Releasing Hormone Agonists*

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Reduced gonadotropin responses in a novel clonal strain of Leydig tumor cells established by transfection of MA-10 cells with a mutant gene of the type I regulatory subunit of the cAMP-dependent protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Hormonal regulation of gonadotropin receptors and steroidogenesis in cultured fetal rat tests

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Effects of 1,2-dibromo-3-chloropropane on male reproductive function in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Toxicologic studies on borax and boric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Androgen Receptor Antagonist versus Agonist Activities of the Fungicide Vinclozolin Relative to Hydroxyflutamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

A Sertoli cell-secreted paracrine factor(s) stimulates proliferation and inhibits steroidogenesis of rat Leydig cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Carcinogenicity studies of oxolinic acid in rats and mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Inhibins, activins, and follistatins: gonadal proteins modulating the secretion of follicle-stimulating hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

Prolactin, Growth Hormone, and Luteinizing Hormone in the Maintenance of Testicular Luteinizing Hormone Receptors*

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

The effects of ethane dimethane sulphonate (EDS) on bilaterally cryptorchid rat testes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/10408449991349203

10.1080/10408449991349203

21 January 2018

Identifiers

DOI

1 reference

28 July 2017

1 reference