PKA, Rap1, ERK1/2, and p90RSK mediate PGE2 and EP4 signaling in neonatal ventricular myocytes (Q33589237)

28 July 2017

title

PKA, Rap1, ERK1/2, and p90RSK mediate PGE2 and EP4 signaling in neonatal ventricular myocytes (English)

1 reference

28 July 2017

Quan He

1

1 reference

28 July 2017

Pamela Harding

series ordinal

2

1 reference

28 July 2017

Margot C LaPointe

series ordinal

3

1 reference

28 July 2017

publication date

30 October 2009

1 reference

American Journal of Physiology Heart and Circulatory Physiology

28 July 2017

published in

1 reference

28 July 2017

volume

298

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28 July 2017

issue

1

1 reference

28 July 2017

page(s)

H136-43

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Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy

28 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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31 October 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Regional differentiation of sympathetic nerve activity during fever caused by intracerebroventricular injection of PGE2

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response

21 June 2018

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21 June 2018

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21 June 2018

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Overexpression of prostaglandin EP3 receptors activates calcineurin and promotes hypertrophy in the murine heart

21 June 2018

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Dose-dependent effect of intracerebroventricular injection of ouabain on the phosphorylation of the MEK1/2-ERK1/2-p90RSK pathway in the rat brain related to locomotor activity

31 October 2018

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Prostaglandin E2 induces hypertrophic changes and suppresses alpha-skeletal actin gene expression in rat cardiomyocytes

31 October 2018

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PGE2 stimulates human brain natriuretic peptide expression via EP4 and p42/44 MAPK.

31 October 2018

1 reference

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cAMP-binding protein Epac induces cardiomyocyte hypertrophy.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806144

Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras.

31 October 2018

1 reference

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PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation

31 October 2018

1 reference

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Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP4.

31 October 2018

1 reference

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Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse

31 October 2018

1 reference

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Epac: a new cAMP target and new avenues in cAMP research

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806144

Distinct Roles of p42/p44<sup>ERK</sup> and p38 MAPK in Oxidant-Induced AP-1 Activation and Cardiomyocyte Hypertrophy

31 October 2018

1 reference

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Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases

31 October 2018

1 reference

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Trophic effects of the cyclooxygenase-2 product prostaglandin E(2) in cardiac myocytes

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806144

PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806144

Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806144

Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806144

Differential regulation of p90 ribosomal S6 kinase and big mitogen-activated protein kinase 1 by ischemia/reperfusion and oxidative stress in perfused guinea pig hearts

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806144

Phorbol ester stimulates the synthesis and secretion of brain natriuretic peptide from neonatal rat ventricular cardiocytes: a comparison with the regulation of atrial natriuretic factor

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806144

Enhancement of pulmonary inflammation by PGE2: evidence for a vasodilator effect

31 October 2018

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12 December 2020

Beta-adrenoceptor and adenylate cyclase regulation in cardiac myocyte growth

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12 December 2020

Effect of inhaled PGE2 on exercise-induced bronchoconstriction in asthmatic subjects

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12 December 2020

Divergent Functional Roles for p90 Kinase Domains

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12 December 2020

Alpha 1-adrenergic stimulation of isolated rat atria results in discoordinate increases in natriuretic peptide secretion and gene expression and enhances Egr-1 and c-Myc expression

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12 December 2020

Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma

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12 December 2020

Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes

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12 December 2020

Glutamine suppresses PGE2 synthesis and breast cancer growth

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12 December 2020

Molecular aspects of mechanical stress-induced cardiac hypertrophy

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12 December 2020

The 90-kDa Ribosomal S6 Kinase (pp90rsk) Phosphorylates the N-terminal Regulatory Domain of IκBα and Stimulates Its Degradation in Vitro

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12 December 2020

Phospholipase A 2 Metabolites Regulate Inducible Nitric Oxide Synthase in Myocytes

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12 December 2020

Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation

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12 December 2020

The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy

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12 December 2020

ERK1/2-p90RSK-mediated phosphorylation of Na /H exchanger isoform 1. A role in ischemic neuronal death

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12 December 2020

Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction

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12 December 2020

10.1152/AJPHEART.00251.2009

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