Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells (Q33588354)

28 July 2017

title

Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells (English)

1 reference

28 July 2017

1 reference

Melissa L Fishel

4

0 references

Millie M. Georgiadis

6

object named as

Millie M Georgiadis

1 reference

28 July 2017

Aditi Bapat

1

1 reference

28 July 2017

Lateca S Glass

2

1 reference

28 July 2017

Meihua Luo

3

1 reference

28 July 2017

Eric C Long

5

1 reference

28 July 2017

Mark R Kelley

7

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28 July 2017

language of work or name

English

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publication date

26 May 2010

1 reference

Journal of Pharmacology and Experimental Therapeutics

28 July 2017

published in

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28 July 2017

volume

334

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28 July 2017

issue

3

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28 July 2017

page(s)

988-998

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Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library

28 July 2017

cites work

1 reference

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14 July 2018

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Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation

14 July 2018

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Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1

14 July 2018

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DNA repair in mammalian cells: Base excision repair: the long and short of it.

14 July 2018

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The many functions of APE1/Ref-1: not only a DNA repair enzyme

14 July 2018

1 reference

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Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease

14 July 2018

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DNA apurinic-apyrimidinic site binding and excision by endonuclease IV

14 July 2018

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Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids

14 July 2018

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Base excision repair of ionizing radiation-induced DNA damage in G1 and G2 cell cycle phases

14 July 2018

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Chemoradiotherapy in malignant glioma: standard of care and future directions

14 July 2018

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The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

14 July 2018

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A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents

14 July 2018

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Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.

14 July 2018

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Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency

14 July 2018

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Isolation of a small molecule inhibitor of DNA base excision repair.

14 July 2018

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Protein-protein interactions and posttranslational modifications in mammalian base excision repair

14 July 2018

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Dynamic monitoring of cytotoxicity on microelectronic sensors

14 July 2018

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Navigating chemical space for biology and medicine

14 July 2018

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Application of real-time cell electronic sensing (RT-CES) technology to cell-based assays

14 July 2018

1 reference

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APE1 is the major 3'-phosphoglycolate activity in human cell extracts

14 July 2018

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Mechanisms of human DNA repair: an update

14 July 2018

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The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress

14 July 2018

1 reference

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The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA.

14 July 2018

1 reference

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A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexp

14 July 2018

1 reference

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Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.

14 July 2018

1 reference

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14 July 2018

Going APE over ref-1.

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

14 July 2018

1 reference

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The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains

14 July 2018

1 reference

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Processing in vitro of an abasic site reacted with methoxyamine: a new assay for the detection of abasic sites formed in vivo.

14 July 2018

1 reference

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Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV

14 July 2018

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

14 July 2018

1 reference

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Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939666

Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939666

The exonuclease activity of human apurinic/apyrimidinic endonuclease (APE1). Biochemical properties and inhibition by the natural dinucleotide Gp4G.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939666

Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939666

Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939666

Detection of abasic sites and oxidative DNA base damage using an ELISA-like assay.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939666

Live cell quality control and utility of real-time cell electronic sensing for assay development

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20504914

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20504914

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/JPET.110.169128

1 reference

28 July 2017

1 reference

28 July 2017

1 reference