Brain-to-blood transporters for endogenous substrates and xenobiotics at the blood-brain barrier: an overview of biology and methodology (Q33569302)

28 July 2017

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title

Brain-to-blood transporters for endogenous substrates and xenobiotics at the blood-brain barrier: an overview of biology and methodology (English)

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28 July 2017

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Sumio Ohtsuki

2

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Tetsuya Terasaki

object named as

Tetsuya Terasaki

series ordinal

1

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publication date

1 January 2005

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28 July 2017

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28 July 2017

volume

2

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28 July 2017

issue

1

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28 July 2017

page(s)

63-72

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Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells

28 July 2017

cites work

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28 July 2018

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28 July 2018

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Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells

28 July 2018

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Localisation of breast cancer resistance protein in microvessel endothelium of human brain

28 July 2018

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Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization

28 July 2018

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GAT2/BGT-1 as a system responsible for the transport of gamma-aminobutyric acid at the mouse blood-brain barrier

28 July 2018

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Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier

28 July 2018

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

28 July 2018

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mRna expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines; a new in vitro BBB model for drug targeting

28 July 2018

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Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier.

28 July 2018

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beta-Amyloid efflux mediated by p-glycoprotein

28 July 2018

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Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

28 July 2018

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Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2.

28 July 2018

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

28 July 2018

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Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier

28 July 2018

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Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539321

Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method

28 July 2018

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Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain

28 July 2018

1 reference

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

28 July 2018

1 reference

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Fine structural localization of a blood-brain barrier to exogenous peroxidase

28 July 2018

1 reference

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Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries.

28 July 2018

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

28 July 2018

1 reference

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Probenecid-induced accumulation of 5-hydroxyindoleacetic acid and homovanillic acid in rat brain

28 July 2018

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Octanoic acid produces accumulation of monoamine acidic metabolites in the brain: interaction with organic anion transport at the choroid plexus

28 July 2018

1 reference

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P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

28 July 2018

1 reference

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Polarity of the Blood-Brain Barrier: Neutral Amino Acid Transport into Isolated Brain Capillaries

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539321

Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes.

28 July 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Particle size analysis of concentrated phospholipid microemulsions I. Total intensity light scattering

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s)

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Characterization of the in vitro uptake of monoamines into brain microvessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Quinolinic acid is extruded from the brain by a probenecid-sensitive carrier system: a quantitative analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Characterization of uremic toxin transport by organic anion transporters in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Involvement of multidrug resistance associated protein 1 (Mrp1) in the efflux transport of 17beta estradiol-D-17beta-glucuronide (E217betaG) across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Rapid transferrin efflux from brain to blood across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1602/NEURORX.2.1.63

Conditionally immortalized brain capillary endothelial cell lines established from a transgenic mouse harboring temperature-sensitive simian virus 40 large T-antigen gene

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539321

In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539321

In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539321

Electron microscopic study of the blood-brain and blood-cerebrospinal fluid barriers with microperoxidase.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=539321

Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

31 October 2018

1 reference

12 December 2020

The blood-brain barrier efflux transporters as a detoxifying system for the brain

1 reference

12 December 2020

Studies on the pathogenesis of uremia comparatie determinaions of glucuronic acid, indican, free and bound phenols in the serum, cerebrospinal fluid, and urine of renal diseases with and without uremia

1 reference

12 December 2020

Brain-to-blood efflux transport of estrone-3-sulfate at the blood-brain barrier in rats

1 reference

12 December 2020

Na( )-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal

1 reference

12 December 2020

Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier

1 reference

12 December 2020

Neutral amino acid transport characterization of isolated luminal and abluminal membranes of the blood-brain barrier

1 reference

12 December 2020

Identifiers

DOI

10.1602/NEURORX.2.1.63

1 reference

28 July 2017

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28 July 2017

1 reference