Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function (Q33556289)

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English	Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 July 2017

Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Sarah C Shuck

1

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Europe PubMed Central

PubMed publication ID

28 July 2017

John J Turchi

2

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Europe PubMed Central

PubMed publication ID

28 July 2017

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publication date

1 April 2010

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Europe PubMed Central

PubMed publication ID

28 July 2017

Cancer Research

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Europe PubMed Central

PubMed publication ID

28 July 2017

70

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Europe PubMed Central

PubMed publication ID

28 July 2017

8

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Europe PubMed Central

PubMed publication ID

28 July 2017

3189-3198

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Europe PubMed Central

PubMed publication ID

28 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2882864/fullTextXML

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Insights into the dynamics of specific telomeric single-stranded DNA recognition by Pot1pN

1 reference

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Fanconi anemia proteins stabilize replication forks

1 reference

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Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints

1 reference

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NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse

1 reference

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The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells

1 reference

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Replication protein A is required for etoposide-induced assembly of MRE11/RAD50/NBS1 complex repair foci.

1 reference

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Replication protein A is an independent prognostic indicator with potential therapeutic implications in colon cancer

1 reference

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A dynamic model for replication protein A (RPA) function in DNA processing pathways

1 reference

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Etoposide, topoisomerase II and cancer

1 reference

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21 June 2018

DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair

1 reference

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21 June 2018

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

1 reference

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DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells

1 reference

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1 reference

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Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.

1 reference

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Development of a high-throughput screen for inhibitors of replication protein A and its role in nucleotide excision repair.

1 reference

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21 June 2018

Physical interaction between replication protein A and Rad51 promotes exchange on single-stranded DNA.

1 reference

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Role of Saccharomyces single-stranded DNA-binding protein RPA in the strand invasion step of double-strand break repair

1 reference

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Nucleic acid recognition by OB-fold proteins

1 reference

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Xeroderma pigmentosum complementation group A protein (XPA) modulates RPA-DNA interactions via enhanced complex stability and inhibition of strand separation activity

1 reference

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RPA facilitates rejoining of DNA double-strand breaks in an in vitro assay utilizing genomic DNA as substrate

1 reference

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Stopped-flow kinetic analysis of replication protein A-binding DNA: damage recognition and affinity for single-stranded DNA reveal differential contributions of k(on) and k(off) rate constants

1 reference

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Structure of the major single-stranded DNA-binding domain of replication protein A suggests a dynamic mechanism for DNA binding

1 reference

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Increased nucleotide excision repair in cisplatin-resistant ovarian cancer cells: role of ERCC1-XPF.

1 reference

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Replication protein A (RPA) binding to duplex cisplatin-damaged DNA is mediated through the generation of single-stranded DNA.

1 reference

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Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases

1 reference

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REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

1 reference

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Bipartite substrate discrimination by human nucleotide excision repair

1 reference

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Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA

1 reference

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Repair of cisplatin--DNA adducts by the mammalian excision nuclease

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Topoisomerase II plays an essential role as a swivelase in the late stage of SV40 chromosome replication in vitro

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1 reference

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10.1158/0008-5472.CAN-09-3422

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Europe PubMed Central

PubMed publication ID

28 July 2017

release_jyjdb5etpbdl5n6sb6dzbozuyq

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24 November 2022

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Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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