Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir (Q33545117)

27 July 2017

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title

Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir (English)

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27 July 2017

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K C Cundy

1

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27 July 2017

publication date

1 February 1999

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Clinical Pharmacokinetics

27 July 2017

published in

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27 July 2017

volume

36

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27 July 2017

issue

2

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27 July 2017

page(s)

127-143

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Clinical pharmacokinetics of probenecid

27 July 2017

cites work

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12 December 2020

Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys

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12 December 2020

Pharmacokinetics of cidofovir in monkeys. Evidence for a prolonged elimination phase representing phosphorylated drug

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12 December 2020

Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).

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12 December 2020

Nursing Considerations in the use of Cidofovir for CMV Retinitis in Patients with AIDS: Report of a Roundtable Meeting

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12 December 2020

Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells

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12 December 2020

(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (cidofovir): results of a phase I/II study of a novel antiviral nucleotide analogue

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12 December 2020

(S)-1-(3-hydroxy-2-(phosphonylmethoxy)propyl)cytosine (HPMPC): a potent antiherpesvirus agent.

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12 December 2020

Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys.

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12 December 2020

Phase I/II study of intravitreal cidofovir for the treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome

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12 December 2020

Pharmacokinetics of stavudine in patients with AIDS or AIDS-related complex

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12 December 2020

Clinical experience with cidofovir in the treatment of cytomegalovirus retinitis

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12 December 2020

Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients

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12 December 2020

Bioavailability and metabolism of cidofovir following topical administration to rabbits

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12 December 2020

Successful Use of Cidofovir in Treating AIDS-Related Cytomegalovirus Retinitis, Encephalitis, and Esophagitis

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12 December 2020

Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells

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12 December 2020

Successful treatment of cytomegalovirus encephalitis in an AIDS patient using cidofovir

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12 December 2020

Recurrent Iritis After Intravenous Administration of Cidofovir

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12 December 2020

Effect of probenecid on the distribution, metabolism, and excretion of cidofovir in rabbits

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12 December 2020

Determination of 9-[(2-phosphonylmethoxy)ethyl]adenine in rat urine by high-performance liquid chromatography with fluorescence detection

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12 December 2020

5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives

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12 December 2020

Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates

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12 December 2020

High-performance liquid chromatographic determination of cytosine-containing compounds by precolumn fluorescence derivatization with phenacyl bromide: application to antiviral nucleosides and nucleotides

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12 December 2020

Intravenous cidofovir for peripheral cytomegalovirus retinitis in patients with AIDS. A randomized, controlled trial

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12 December 2020

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

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12 December 2020

Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats

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12 December 2020

Cidofovir: a new therapy for cytomegalovirus retinitis

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12 December 2020

Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects

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12 December 2020

Treatment of adenoviral conjunctivitis with topical cidofovir

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12 December 2020

Isolation and identification of a metabolite of cidofovir from rat kidney

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12 December 2020

A Randomized, Double‐Blind, Placebo‐Controlled Trial of Cidofovir Gel for the Treatment of Acyclovir‐Unresponsive Mucocutaneous Herpes Simplex Virus Infection in Patients with AIDS

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12 December 2020

Biochemical pharmacology of acyclic nucleotide analogues

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12 December 2020

Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine

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12 December 2020

Anti‐Human Immunodeficiency Virus (HIV) Activity, Safety, and Pharmacokinetics of Adefovir Dipivoxil (9‐[2‐(bis‐pivaloyloxymethyl)‐phosphonylmethoxyethyl]adenine) in HIV‐Infected Patients

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12 December 2020

Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys

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12 December 2020

Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats

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12 December 2020

Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients

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12 December 2020

Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection

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12 December 2020

Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits

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12 December 2020

Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine

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12 December 2020

Oral Formulations of Adefovir Dipivoxil: In Vitro Dissolution and in Vivo Bioavailability in Dogs

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12 December 2020

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent

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12 December 2020

The use of probenecid as a chemoprotector against cisplatin nephrotoxicity

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12 December 2020

Optimization of in vitro flux through hairless mouse skin of cidofovir, a potent nucleotide analog

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12 December 2020

Relationship between the Transport and Toxicity of Cephalosporins in the Kidney

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12 December 2020

Treatment of acyclovir-resistant herpes simplex virus infections in patients with AIDS

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12 December 2020

10.2165/00003088-199936020-00004

Identifiers

DOI

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Dimensions Publication ID

27 July 2017

1051828923

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