Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3. (Q33522863)

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English	Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3.	scientific article

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16 January 2020

Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3 (English)

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16 January 2020

Gerald H Lushington

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16 January 2020

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16 January 2020

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Dengfeng Dou

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16 January 2020

Guijia He

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16 January 2020

Yi Li

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16 January 2020

Zhong Lai

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16 January 2020

Liuqing Wei

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16 January 2020

Kevin R Alliston

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16 January 2020

William C Groutas

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16 January 2020

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29 December 2009

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16 January 2020

Bioorganic & Medicinal Chemistry

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16 January 2020

18

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16 January 2020

3

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16 January 2020

1093-1102

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16 January 2020

Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding.

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Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase

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Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions

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The growing applications of click chemistry

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Scaffold selection and scaffold hopping in lead generation: a medicinal chemistry perspective

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Pharmacological therapy for Wegener's granulomatosis.

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Neutrophil elastase: mediator of extracellular matrix destruction and accumulation

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Ruthenium-catalyzed cycloaddition of alkynes and organic azides

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Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease

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The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years

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Neutrophil serine proteases: potential key regulators of cell signalling during inflammation

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28 July 2018

Proteases and emphysema

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Mediators of chronic obstructive pulmonary disease

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Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice

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Alveolar wall apoptosis causes lung destruction and emphysematous changes

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Proteases and lung injury

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Surflex: fully automatic flexible molecular docking using a molecular similarity-based search engine

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A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

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Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates

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Neutrophils and protease/antiprotease imbalance

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Inflammation and repair processes in chronic obstructive pulmonary disease

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Inhibition of neutrophil elastase in CF sputum by L-658,758

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The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies

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On the size of the active site in proteases. I. Papain

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Substrate and inhibitor studies on proteinase 3

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Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters

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Reversible and competitive cinnamoyl triazole inhibitors of tissue transglutaminase.

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31 October 2018

Neutrophil serine proteases: specific regulators of inflammation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853038

31 October 2018

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Design of selective substrates of proteinase 3 using combinatorial chemistry methods

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Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3

1 reference

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Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide

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Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates

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Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

1 reference

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Scaffold hopping

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Synthesis of Optically Active Phthaloyld-Aminooxy Acids froml-Amino Acids orl-Hydroxy Acids as Building Blocks for the Preparation of Aminooxy Peptides

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10.1016/J.BMC.2009.12.057

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16 January 2020

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16 January 2020

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16 January 2020

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