On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist (Q33508413)

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English	On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Paween Mahinthichaichan

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Paween Mahinthichaichan

3

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author name string

Mathew T Mizwicki

1

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Craig M Bula

2

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Europe PubMed Central

PubMed publication ID

27 July 2017

Helen L Henry

4

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Seiichi Ishizuka

5

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Europe PubMed Central

PubMed publication ID

27 July 2017

Anthony W Norman

6

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Europe PubMed Central

PubMed publication ID

27 July 2017

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publication date

28 September 2009

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Europe PubMed Central

PubMed publication ID

27 July 2017

number of pages

10

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Journal of Biological Chemistry

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Europe PubMed Central

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27 July 2017

284

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Europe PubMed Central

PubMed publication ID

27 July 2017

52

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Europe PubMed Central

PubMed publication ID

27 July 2017

36292-36301

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

The vitamin D sterol-vitamin D receptor ensemble model offers unique insights into both genomic and rapid-response signaling

1 reference

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21 June 2018

New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

A structural basis for the species-specific antagonism of 26,23-lactones on vitamin D signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Paget's disease-a VDR coactivator disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Vitamin D: more than a "bone-a-fide" hormone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Enhancement of VDR-mediated transcription by phosphorylation: correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting protein coactivator complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

(23S)- and (23R)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone function as antagonists of vitamin D receptor-mediated genomic actions of 1alpha,25-dihydroxyvitamin D(3).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

25-Dehydro-1alpha-hydroxyvitamin D3-26,23S-lactone antagonizes the nuclear vitamin D receptor by mediating a unique noncovalent conformational change

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Ligand-protein interactions in nuclear receptors of hormones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Molecular basis of agonism and antagonism in the oestrogen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Distinct conformational changes induced by 20-epi analogues of 1 alpha,25-dihydroxyvitamin D3 are associated with enhanced activation of the vitamin D receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

An hydroxylapatite batch assay for the quantitation of 1α,25-dihydroxyvitamin D3-receptor complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

21 June 2018

Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a rec

1 reference

https://api.crossref.org/works/10.1074/JBC.M109.042069

21 January 2018

Molecular mechanism of the vitamin D antagonistic actions of (23S)-25-dehydro-1alpha-hydroxyvitamin D3-26,23-lactone depends on the primary structure of the carboxyl-terminal region of the vitamin d receptor

1 reference

https://api.crossref.org/works/10.1074/JBC.M109.042069

21 January 2018

(23S)-25-Dehydro-1{alpha}-hydroxyvitamin D3-26,23-lactone, a vitamin D receptor antagonist that inhibits osteoclast formation and bone resorption in bone marrow cultures from patients with Paget's disease

1 reference

https://api.crossref.org/works/10.1074/JBC.M109.042069

21 January 2018

Synthesis and structure-activity relationships of TEI-9647 derivatives as Vitamin D3 antagonists

1 reference

https://api.crossref.org/works/10.1074/JBC.M109.042069

21 January 2018

Presence of a truncated form of the vitamin D receptor (VDR) in a strain of VDR-knockout mice

1 reference

https://api.crossref.org/works/10.1074/JBC.M109.042069

21 January 2018

Generalized born model with a simple smoothing function.

1 reference

https://api.crossref.org/works/10.1074/JBC.M109.042069

21 January 2018

Study of the insulin dimerization: binding free energy calculations and per-residue free energy decomposition

1 reference

https://api.crossref.org/works/10.1074/JBC.M109.042069

21 January 2018

Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1alpha,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysis

1 reference

https://api.crossref.org/works/10.1074/JBC.M109.042069

21 January 2018

Structurally and functionally important amino acids of the agonistic conformation of the human vitamin D receptor

1 reference

https://api.crossref.org/works/10.1074/JBC.M109.042069

21 January 2018

Ligand recognition by the vitamin D receptor

1 reference

https://api.crossref.org/works/10.1074/JBC.M109.042069

21 January 2018

Different molecular mechanisms of vitamin D(3) receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2794745

31 October 2018

Antagonistic action of novel 1alpha,25-dihydroxyvitamin D3-26, 23-lactone analogs on differentiation of human leukemia cells (HL-60) induced by 1alpha,25-dihydroxyvitamin D3

1 reference

https://pubmed.ncbi.nlm.nih.gov/19801650

12 December 2020

based on heuristic

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1alpha,25-dihydroxyvitamin D(3)-26,23-lactone analogs antagonize differentiation of human leukemia cells (HL-60 cells) but not of human acute promyelocytic leukemia cells (NB4 cells)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19801650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced biological activity of 1alpha,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1alpha,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19801650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.042069

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

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