Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase (Q33507261)

27 July 2017

title

Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase (English)

1 reference

27 July 2017

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Geert A Martens

6

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Karine H Hellemans

object named as

Karine H Hellemans

1

0 references

Daniel Pipeleers

9

object named as

Daniel Pipeleers

1 reference

27 July 2017

7

Paul P Van Veldhoven

1 reference

27 July 2017

Jean-Claude Hannaert

2

1 reference

27 July 2017

Bart Denys

3

1 reference

27 July 2017

Knut R Steffensen

4

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27 July 2017

Cindy Raemdonck

5

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27 July 2017

Jan-Ake Gustafsson

8

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27 July 2017

language of work or name

English

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publication date

29 September 2009

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27 July 2017

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27 July 2017

volume

4

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27 July 2017

issue

9

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27 July 2017

page(s)

e7266

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Creative Commons Attribution 4.0 International

27 July 2017

copyright license

start time

29 September 2009

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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21 June 2018

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Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice

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21 June 2018

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Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.

21 June 2018

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Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels

21 June 2018

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Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

21 June 2018

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21 June 2018

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21 June 2018

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Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

21 June 2018

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Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

21 June 2018

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ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

21 June 2018

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Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells

21 June 2018

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21 June 2018

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Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

21 June 2018

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Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

21 June 2018

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Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

21 June 2018

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

21 June 2018

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21 June 2018

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Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

21 June 2018

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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

21 June 2018

1 reference

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Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746288

Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746288

Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746288

Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program

21 June 2018

1 reference

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Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB.

21 June 2018

1 reference

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Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746288

Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity

21 June 2018

1 reference

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Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

21 June 2018

1 reference

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Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PONE.0007266

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

21 January 2018

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Different role of saturated and unsaturated fatty acids in beta-cell apoptosis

21 January 2018

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Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity

21 January 2018

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LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

21 January 2018

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Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes

21 January 2018

1 reference

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Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death

21 January 2018

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Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.

21 January 2018

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Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

21 January 2018

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Mouse Elovl-6 promoter is an SREBP target

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0007266

Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0007266

Sterol regulatory element-binding protein-1c and pancreatic beta-cell dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0007266

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0007266

Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PONE.0007266

Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PONE.0007266

Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PONE.0007266

Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PONE.0007266

Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PONE.0007266

Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus.

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746288

Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro

31 October 2018

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12 December 2020

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12 December 2020

A new in vitro model for the study of pancreatic A and B cells

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12 December 2020

Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells

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Effect of dietary lipids and endocrine changes on polyunsaturated fatty acids in phospholipids of pancreas and brown adipose tissue of obese and lean rats

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Long-term effect of bezafibrate on pancreatic beta-cell function and insulin resistance in patients with diabetes

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12 December 2020

Long-Term Predictors of Insulin Resistance: Role of lifestyle and metabolic factors in middle-aged men

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Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha

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12 December 2020

10.1371/JOURNAL.PONE.0007266

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27 July 2017

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27 July 2017

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