The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans (Q33506593)

27 July 2017

title

The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans (English)

1 reference

Checkpoint protein CELE_H26D21.1

27 July 2017

main subject

Caenorhabditis elegans

0 references

1 reference

Cell cycle checkpoint protein RAD1 homolog mrt-2 CELE_Y41C4A.14

1 reference

MoRTal germline CELE_F39H2.5

1 reference

Telomerase reverse transcriptase CELE_DY3.4

1 reference

Louise J Barber

2

0 references

Anton Gartner

object named as

Anton Gartner

6

0 references

author name string

Bettina Meier

1

1 reference

27 July 2017

Yan Liu

3

1 reference

27 July 2017

Ludmila Shtessel

4

1 reference

27 July 2017

Simon J Boulton

5

1 reference

27 July 2017

Shawn Ahmed

7

1 reference

27 July 2017

language of work or name

English

0 references

publication date

24 September 2009

1 reference

27 July 2017

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27 July 2017

volume

28

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27 July 2017

issue

22

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27 July 2017

page(s)

3549-3563

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End joining at Caenorhabditis elegans telomeres

27 July 2017

cites work

1 reference

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The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2.

21 June 2018

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Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation

21 June 2018

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Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

21 June 2018

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C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins

21 June 2018

1 reference

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Mammalian SNM1 is required for genome stability

21 June 2018

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Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation

21 June 2018

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Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants

21 June 2018

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Human diseases of telomerase dysfunction: insights into tissue aging

21 June 2018

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Dyskeratosis congenita: the diverse clinical presentation of mutations in the telomerase complex

21 June 2018

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The hSNM1 protein is a DNA 5'-exonuclease

21 June 2018

1 reference

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Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance

21 June 2018

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Nucleases of the metallo-beta-lactamase family and their role in DNA and RNA metabolism

21 June 2018

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The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication

21 June 2018

1 reference

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The POT1-TPP1 telomere complex is a telomerase processivity factor

21 June 2018

1 reference

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TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

21 June 2018

1 reference

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Replication fork regression in repetitive DNAs

21 June 2018

1 reference

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The biogenesis and regulation of telomerase holoenzymes

21 June 2018

1 reference

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Apollo, an Artemis-related nuclease, interacts with TRF2 and protects human telomeres in S phase

21 June 2018

1 reference

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The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair

21 June 2018

1 reference

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Developmental modulation of nonhomologous end joining in Caenorhabditis elegans

21 June 2018

1 reference

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hSnm1B is a novel telomere-associated protein

21 June 2018

1 reference

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A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator

21 June 2018

1 reference

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trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Human telomeres have different overhang sizes at leading versus lagging strands

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

The Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Switching human telomerase on and off with hPOT1 protein in vitro

21 June 2018

1 reference

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Artemis links ATM to double strand break rejoining

21 June 2018

1 reference

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Loss of hPot1 function leads to telomere instability and a cut-like phenotype

21 June 2018

1 reference

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The yeast Snm1 protein is a DNA 5'-exonuclease

21 June 2018

1 reference

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Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection

21 June 2018

1 reference

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Human SNM1B is required for normal cellular response to both DNA interstrand crosslink-inducing agents and ionizing radiation

21 June 2018

1 reference

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Prediction of multiple tandem OB-fold domains in telomere end-binding proteins Pot1 and Cdc13.

21 June 2018

1 reference

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Functional links between telomeres and proteins of the DNA-damage response

21 June 2018

1 reference

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A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length

21 June 2018

1 reference

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A human telomerase-associated nuclease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Human telomerase catalyzes nucleolytic primer cleavage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Functional and biochemical dissection of the structure-specific nuclease ARTEMIS

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

The beta-lactamase motif in Snm1 is required for repair of DNA double-strand breaks caused by interstrand crosslinks in S. cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

An evolutionary classification of the metallo-beta-lactamase fold proteins.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Pot1, the putative telomere end-binding protein in fission yeast and humans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Characterization of the interaction between the nuclease and reverse transcriptase activity of the yeast telomerase complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Mammalian telomeres end in a large duplex loop

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Negative regulation of yeast telomerase activity through an interaction with an upstream region of the DNA primer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Flexible Positioning of the Telomerase-Associated Nuclease Leads to Preferential Elimination of Nontelomeric DNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Developmentally regulated initiation of DNA synthesis by telomerase: evidence for factor-assisted de novo telomere formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Telomeric repeats (TTAGGC)n are sufficient for chromosome capping function in Caenorhabditis elegans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Processing of nontelomeric 3' ends by telomerase: default template alignment and endonucleolytic cleavage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

A single amino acid change in SNM1-encoded protein leads to thermoconditional deficiency for DNA cross-link repair in Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

Isolation and characterization of pso mutants sensitive to photo-addition of psoralen derivatives in Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

The fate of 8-methoxypsoralen photoinduced crosslinks in nuclear and mitochondrial yeast DNA: comparison of wild-type and repair-deficient strains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782091

MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans

21 June 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.278

Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links

21 January 2018

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https://api.crossref.org/works/10.1038/EMBOJ.2009.278

21 January 2018

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https://api.crossref.org/works/10.1038/EMBOJ.2009.278

Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038/EMBOJ.2009.278

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues

21 January 2018

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https://api.crossref.org/works/10.1038/EMBOJ.2009.278

Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates.

21 January 2018

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https://api.crossref.org/works/10.1038/EMBOJ.2009.278

Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/EMBOJ.2009.278

Characterization of mutations induced by ethyl methanesulfonate, UV, and trimethylpsoralen in the nematode Caenorhabditis elegans

21 January 2018

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12 December 2020

Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation

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12 December 2020

Functional reconstitution of wild-type and mutant Tetrahymena telomerase

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12 December 2020

C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair

1 reference

12 December 2020

Telomere and Telomerase Modulation by the Mammalian Rad9/Rad1/Hus1 DNA-Damage-Checkpoint Complex

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2009.278

1 reference

27 July 2017

1 reference

27 July 2017

1 reference