RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway (Q33494047)

27 July 2017

title

RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway (English)

1 reference

27 July 2017

1 reference

Angela M Keuling

1

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27 July 2017

Kathleen E A Felton

2

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27 July 2017

Arabesque A M Parker

3

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27 July 2017

Majid Akbari

4

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27 July 2017

Susan E Andrew

5

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27 July 2017

Victor A Tron

6

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27 July 2017

language of work or name

English

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publication date

17 August 2009

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27 July 2017

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27 July 2017

volume

4

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27 July 2017

issue

8

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27 July 2017

page(s)

e6651

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Creative Commons Attribution 4.0 International

27 July 2017

copyright license

start time

17 August 2009

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis.

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

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ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells.

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21 June 2018

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The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.

21 June 2018

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

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21 June 2018

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21 June 2018

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21 June 2018

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

21 June 2018

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BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

21 June 2018

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21 June 2018

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21 June 2018

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21 January 2018

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

21 January 2018

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21 January 2018

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Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death

21 January 2018

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Bcl-2 family proteins are essential for platelet survival.

21 January 2018

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The statistics of synergism

31 October 2018

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12 December 2020

Expression of apoptosis regulators in cutaneous malignant melanoma

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12 December 2020

Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma

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12 December 2020

A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers

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12 December 2020

Myeloid leukemia-1 expression in benign and malignant melanocytic lesions

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12 December 2020

Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma

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12 December 2020

10.1371/JOURNAL.PONE.0006651

Identifiers

DOI

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27 July 2017

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27 July 2017

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