Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity (Q33396651)

26 July 2017

title

Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity (English)

1 reference

26 July 2017

Jason A Pfister

1

1 reference

26 July 2017

Chi Ma

series ordinal

2

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26 July 2017

Brad E Morrison

series ordinal

3

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26 July 2017

Santosh R D'Mello

series ordinal

4

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26 July 2017

language of work or name

English

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publication date

31 December 2008

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26 July 2017

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26 July 2017

volume

3

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26 July 2017

issue

12

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26 July 2017

page(s)

e4090

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Creative Commons Attribution 4.0 International

26 July 2017

copyright license

start time

31 December 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase

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Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.

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Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases

21 June 2018

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21 June 2018

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SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

21 June 2018

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SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes

21 June 2018

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Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells

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21 June 2018

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21 June 2018

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Paths of convergence: sirtuins in aging and neurodegeneration

21 June 2018

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SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome

21 June 2018

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SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts

21 June 2018

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The Sirtuin family: therapeutic targets to treat diseases of aging

21 June 2018

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Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

21 June 2018

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Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53

21 June 2018

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Negative regulation of the deacetylase SIRT1 by DBC1

21 June 2018

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DBC1 is a negative regulator of SIRT1

21 June 2018

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Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection

21 June 2018

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Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5

21 June 2018

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AROuSing SIRT1: identification of a novel endogenous SIRT1 activator.

21 June 2018

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A therapeutic role for sirtuins in diseases of aging?

21 June 2018

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Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity

21 June 2018

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Sirt1 modulates premature senescence-like phenotype in human endothelial cells

21 June 2018

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Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation

21 June 2018

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Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

21 June 2018

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Sirtuins: critical regulators at the crossroads between cancer and aging

21 June 2018

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SIRT1 activation confers neuroprotection in experimental optic neuritis

21 June 2018

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Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 June 2018

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

21 June 2018

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Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs

21 June 2018

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Cytoplasm-localized SIRT1 enhances apoptosis

21 June 2018

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Resveratrol stimulates AMP kinase activity in neurons

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Nucleocytoplasmic shuttling of the NAD -dependent histone deacetylase SIRT1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 June 2018

1 reference

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A probability-based approach for high-throughput protein phosphorylation analysis and site localization

21 June 2018

1 reference

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Resveratrol--a boon for treating Alzheimer's disease?

21 June 2018

1 reference

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SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

21 June 2018

1 reference

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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

21 June 2018

1 reference

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Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD( ) cosubstrate specificity of a Sir2 enzyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Large-scale characterization of HeLa cell nuclear phosphoproteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

The human Sir2 ortholog, SIRT2, is an NAD -dependent tubulin deacetylase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

Apoptosis in cerebellar granule neurons is associated with reduced interaction between CREB-binding protein and NF-kappaB.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaBbeta [correction of Ikappabeta] phosphorylation with cell survival

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605257

10.1371/JOURNAL.PONE.0004090

31 October 2018

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DOI

1 reference

release_wxbk5lvssvhb5hvugzd72xhb7e

26 July 2017

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mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

2605257

1 reference

26 July 2017

1 reference