Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis (Q33389544)

26 July 2017

title

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis (English)

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26 July 2017

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Narcis I Popescu

3

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John D. Lambris

object named as

John D Lambris

12

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Tom Eirik Mollnes

9

object named as

Tom E Mollnes

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26 July 2017

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Georgia Sfyroera

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26 July 2017

Robert Silasi-Mansat

1

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26 July 2017

Hua Zhu

2

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26 July 2017

Glenn Peer

4

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26 July 2017

Paola Magotti

6

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26 July 2017

Lacramioara Ivanciu

7

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26 July 2017

Cristina Lupu

8

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26 July 2017

Fletcher B Taylor

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26 July 2017

Gary Kinasewitz

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26 July 2017

Florea Lupu

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26 July 2017

language of work or name

English

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publication date

13 May 2010

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26 July 2017

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26 July 2017

volume

116

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26 July 2017

issue

6

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26 July 2017

page(s)

1002-1010

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Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1

26 July 2017

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21 June 2018

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CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Hypothesis: combined inhibition of complement and CD14 as treatment regimen to attenuate the inflammatory response.

21 June 2018

1 reference

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Complexity of complement activation in sepsis

21 June 2018

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Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition

21 June 2018

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Thrombin-thrombomodulin connects coagulation and fibrinolysis: more than an in vitro phenomenon

21 June 2018

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Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor.

21 June 2018

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The role of complement in inflammatory diseases from behind the scenes into the spotlight

21 June 2018

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Complement and coagulation: strangers or partners in crime?

21 June 2018

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Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis

21 June 2018

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The cytoprotective protein C pathway

21 June 2018

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Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis

21 June 2018

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Tissue factor-dependent coagulation is preferentially up-regulated within arterial branching areas in a baboon model of Escherichia coli sepsis

21 June 2018

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Platelet activation leads to activation and propagation of the complement system

21 June 2018

1 reference

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Electrostatic modeling predicts the activities of orthopoxvirus complement control proteins

21 June 2018

1 reference

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The impact of the inflammatory response on coagulation

21 June 2018

1 reference

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The dark side of C5a in sepsis

21 June 2018

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Role for the alternative complement pathway in ischemia/reperfusion injury

21 June 2018

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21 June 2018

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Staging of the pathophysiologic responses of the primate microvasculature to Escherichia coli and endotoxin: examination of the elements of the compensated response and their links to the corresponding uncompensated lethal variants

21 June 2018

1 reference

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Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

21 June 2018

1 reference

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Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library.

21 June 2018

1 reference

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Activation of the complement system in baboons challenged with live Escherichia coli: correlation with mortality and evidence for a biphasic activation pattern

21 June 2018

1 reference

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Studies on the inflammatory-coagulant axis in the baboon response to E. coli: regulatory roles of proteins C, S, C4bBP and of inhibitors of tissue factor

21 June 2018

1 reference

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Human platelet activation by C3a and C3a des-arg

21 June 2018

1 reference

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The response of human platelets to activated components of the complement system

21 June 2018

1 reference

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Combined inhibition of complement and CD14 abolish E. coli-induced cytokine-, chemokine- and growth factor-synthesis in human whole blood.

21 June 2018

1 reference

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Compstatin, a peptide inhibitor of complement, exhibits species-specific binding to complement component C3.

31 October 2018

1 reference

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Complement and leukocyte activation in septic baboons.

31 October 2018

1 reference

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Inhibition of Heparin/Protamine Complex-Induced Complement Activation by Compstatin in Baboons

31 October 2018

1 reference

12 December 2020

The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis

1 reference

12 December 2020

Complement activation in septic baboons detected by neoepitope-specific assays for C3b/iC3b/C3c, C5a and the terminal C5b-9 complement complex (TCC)

1 reference

12 December 2020

Tubing loops as a model for cardiopulmonary bypass circuits: both the biomaterial and the blood-gas phase interfaces induce complement activation in an in vitro model

1 reference

12 December 2020

Generation of C5a in the absence of C3: a new complement activation pathway

1 reference

12 December 2020

Hydrophobic Effect and Hydrogen Bonds Account for the Improved Activity of a Complement Inhibitor, Compstatin

1 reference

12 December 2020

Observations on complement activity in the two-stage inflammatory/hemostatic response in the baboon and human models of E. coli sepsis and endotoxemia

1 reference

12 December 2020

10.1182/BLOOD-2010-02-269746

Identifiers

DOI

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26 July 2017

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26 July 2017

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