Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential (Q33374015)

26 July 2017

title

Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential (English)

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26 July 2017

5

Astra Dinculescu

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author name string

Qiuhong Li

1

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26 July 2017

Rehae Miller

2

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26 July 2017

Ping-Yang Han

3

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26 July 2017

Jijing Pang

4

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26 July 2017

Astra Dinculescu

5

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26 July 2017

Vince Chiodo

6

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26 July 2017

William W Hauswirth

7

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26 July 2017

publication date

24 September 2008

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26 July 2017

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26 July 2017

volume

14

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26 July 2017

page(s)

1760-1769

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Versatility of AAV vectors for retinal gene transfer

26 July 2017

cites work

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Restoration of cone vision in a mouse model of achromatopsia

14 July 2018

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Immunosuppressive properties of the pigmented epithelial cells and the subretinal space

14 July 2018

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The induction of anterior chamber-associated immune deviation

14 July 2018

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AAV-mediated gene transfer for retinal diseases

14 July 2018

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A historical perspective on immunological privilege

14 July 2018

1 reference

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Gene therapy progress and prospects: the eye.

14 July 2018

1 reference

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Adeno-associated viral vectors for retinal gene transfer and treatment of retinal diseases

14 July 2018

1 reference

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Immune responses to adeno-associated virus vectors

14 July 2018

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Adeno-associated virus-vectored gene therapy for retinal disease

14 July 2018

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Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain

14 July 2018

1 reference

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Immune response against gene therapy vectors: influence of synovial fluid on adeno-associated virus mediated gene transfer to chondrocytes

14 July 2018

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Striatal delivery of rAAV-hAADC to rats with preexisting immunity to AAV.

14 July 2018

1 reference

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Range of retinal diseases potentially treatable by AAV-vectored gene therapy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Ocular immune privilege: therapeutic opportunities from an experiment of nature

14 July 2018

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Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation

14 July 2018

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Immune responses to adeno-associated virus and its recombinant vectors

14 July 2018

1 reference

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Immune privilege in the anterior chamber of the eye.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization

14 July 2018

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Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

14 July 2018

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Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Production and purification of recombinant adeno-associated virus

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Epitope mapping of human anti-adeno-associated virus type 2 neutralizing antibodies: implications for gene therapy and virus structure

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Immune responses to adenovirus and adeno-associated virus in humans.

14 July 2018

1 reference

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Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

The Gordon Wilson Lecture. From basic virology to human gene therapy.

14 July 2018

1 reference

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Successful readministration of adeno-associated virus vectors to the mouse lung requires transient immunosuppression during the initial exposure

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Analysis of immune deviation elicited by antigens injected into the subretinal space.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Human retinal pigment epithelial cell-induced apoptosis in activated T cells.

14 July 2018

1 reference

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Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration.

14 July 2018

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Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virus

14 July 2018

1 reference

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The role of FasL-induced apoptosis in immune privilege

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein

14 July 2018

1 reference

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Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector

14 July 2018

1 reference

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A seroepidemiologic study of adenovirus-associated virus infection in infants and children

14 July 2018

1 reference

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Epidemiology of adenovirus-associated virus infection in a nursery population

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Isolation of adenovirus-associated viruses from man.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Production of latent transforming growth factor-beta and other inhibitory factors by cultured murine iris and ciliary body cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Cone-specific expression using a human red opsin promoter in recombinant AAV.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

The analysis of systemic tolerance elicited by antigen inoculation into the vitreous cavity: vitreous cavity-associated immune deviation

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

A deviant immune response to viral proteins and transgene product is generated on subretinal administration of adenovirus and adeno-associated virus

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Factors influencing the development of an anti-factor IX (FIX) immune response following administration of adeno-associated virus-FIX.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Route of administration determines induction of T-cell-independent humoral responses to adeno-associated virus vectors.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Additional transduction events after subretinal readministration of recombinant adeno-associated virus

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Update on the prevalence of serum antibodies (IgG and IgM) to adeno-associated virus (AAV).

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Evidence for infection of the human embryo with adeno-associated virus in pregnancy

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Transient Immunosuppression Allows Transgene Expression Following Readministration of Adeno-Associated Viral Vectors

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Local inhibition of natural killer cell activity promotes the progressive growth of intraocular tumors.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Cytotoxic T Lymphocyte Activity after Intravitreal Inoculation of Herpes simplex Virus Type I in Mice

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2559816

Immune privilege is extended, then withdrawn, from allogeneic tumor cell grafts placed in the subretinal space

31 October 2018

1 reference

12 December 2020

Blood-borne signals that induce anterior chamber-associated immune deviation after intracameral injection of antigen

1 reference

12 December 2020

Serologic evidence for human infection with adenovirus-associated viruses

1 reference

12 December 2020

Deviant immune responses to allogeneic tumors injected intracamerally and subcutaneously in mice

1 reference

12 December 2020

Retinitis and deviant immune responses following intravitreal inoculation of HSV-1

1 reference

12 December 2020

Immune privilege extended to allogeneic tumor cells in the vitreous cavity

1 reference

12 December 2020

Analysis of immunosuppressive properties of iris and ciliary body cells and their secretory products

1 reference

12 December 2020

Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts

1 reference

12 December 2020

Immunologic consequences of intraocular implantation of retinal pigment epithelial allografts

1 reference

12 December 2020

Unconventional rejection of neural retinal allografts implanted into the immunologically privileged site of the eye

1 reference

12 December 2020

Identifiers

PMC publication ID

2559816

1 reference

26 July 2017

1 reference