Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes (Q33290356)

25 July 2017

title

Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes (English)

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25 July 2017

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Michael A Fischbach

1

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Christopher T. Walsh

series ordinal

4

object named as

Christopher T Walsh

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25 July 2017

Jonathan R Lai

2

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25 July 2017

Eric D Roche

series ordinal

3

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25 July 2017

David R Liu

series ordinal

5

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25 July 2017

language of work or name

English

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publication date

9 July 2007

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25 July 2017

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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25 July 2017

volume

104

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25 July 2017

issue

29

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25 July 2017

page(s)

11951-11956

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Molecular engineering approaches to peptide, polyketide and other antibiotics

25 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

Combinatorial biosynthesis of novel antibiotics related to daptomycin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

Interdomain communication between the thiolation and thioesterase domains of EntF explored by combinatorial mutagenesis and selection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid

21 June 2018

1 reference

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Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

Novel bacterial acetyl coenzyme A carboxylase inhibitors with antibiotic efficacy in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

How pathogenic bacteria evade mammalian sabotage in the battle for iron

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

Molecular characterization and analysis of the operon encoding the antifungal lipopeptide bacillomycin D.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

Construction of hybrid peptide synthetases by module and domain fusions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

Construction and in vitro analysis of a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1924863

Characterization of the syringomycin synthetase gene cluster. A link between prokaryotic and eukaryotic peptide synthetases

21 June 2018

1 reference

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Reconstitution and Characterization of the Escherichia coli Enterobactin Synthetase from EntB, EntE, and EntF

21 June 2018

1 reference

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The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases

21 June 2018

1 reference

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An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues

21 June 2018

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Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics

21 June 2018

1 reference

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Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0705348104

Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0705348104

Dissection of the EntF condensation domain boundary and active site residues in nonribosomal peptide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0705348104

Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0705348104

Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073/PNAS.0705348104

Dipeptide formation on engineered hybrid peptide synthetases

21 January 2018

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12 December 2020

Recombinant acylheptapeptide lichenysin: high level of production by Bacillus subtilis cells

1 reference

12 December 2020

Rational Design of Peptide Antibiotics by Targeted Replacement of Bacterial and Fungal Domains

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12 December 2020

Targeted alteration of the substrate specificity of peptide synthetases by rational module swapping

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12 December 2020

Harnessing the biosynthetic code: combinations, permutations, and mutations

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12 December 2020

In vivo biocombinatorial synthesis of lipopeptides by COM domain-mediated reprogramming of the surfactin biosynthetic complex

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12 December 2020

Complementation of daptomycin dptA and dptD deletion mutations in trans and production of hybrid lipopeptide antibiotics

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0705348104

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25 July 2017

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25 July 2017

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