Trisubstituted (E)-alkene dipeptide isosteres as beta-turn promoters in the gramicidin S cyclodecapeptide scaffold (Q33259315)

24 July 2017

title

Trisubstituted (E)-alkene dipeptide isosteres as beta-turn promoters in the gramicidin S cyclodecapeptide scaffold (English)

1 reference

24 July 2017

3

Peter Wipf

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24 July 2017

Jingbo Xiao

1

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24 July 2017

Bernard Weisblum

series ordinal

2

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24 July 2017

language of work or name

English

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publication date

1 October 2006

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24 July 2017

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24 July 2017

volume

8

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24 July 2017

issue

21

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24 July 2017

page(s)

4731-4734

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Beta-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product

24 July 2017

cites work

1 reference

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Convergent approach to (E)-alkene and cyclopropane peptide isosteres

21 June 2018

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Phage display-derived peptides as therapeutic alternatives to antibodies

21 June 2018

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Catalytic asymmetric addition of diorganozinc reagents to N-phosphinoylalkylimines

21 June 2018

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Stereochemistry of protected ornithine side chains of gramicidin S derivatives: X-ray crystal structure of the bis-Boc-tetra-N-methyl derivative of gramicidin S

21 June 2018

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Effect of sequence on peptide geometry in 5-tert-butylprolyl type VI beta-turn mimics.

21 June 2018

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Mitochondrial targeting of selective electron scavengers: synthesis and biological analysis of hemigramicidin-TEMPO conjugates

21 June 2018

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Reduction of Peptide Character of HIV Protease Inhibitors That Exhibit Nanomolar Potency against Multidrug Resistant HIV-1 Strains

31 October 2018

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Serine-cis-proline and serine-trans-proline isosteres: stereoselective synthesis of (Z)- and (E)-alkene mimics by Still-Wittig and Ireland-Claisen rearrangements

31 October 2018

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Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-S(N)2' reactions

31 October 2018

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Antiparallel pleated beta-sheets observed in crystal structures of N,N-bis(trichloroacetyl) and N,N-bis(m-bromobenzoyl) gramicidin S.

31 October 2018

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Three-component aldimine addition--cyclopropanation. an efficient new methodology for amino cyclopropane synthesis

31 October 2018

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Modulation of structure and antibacterial and hemolytic activity by ring size in cyclic gramicidin S analogs

31 October 2018

1 reference

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Optimized Protocol for Synthesis of Cyclic Gramicidin S: Starting Amino Acid Is Key to High Yield

31 October 2018

1 reference

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Peptide Bond Isosteres: Ester or (E)-Alkene in the Backbone of the Collagen Triple Helix

31 October 2018

1 reference

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Electrostatic versus steric effects in peptidomimicry: synthesis and secondary structure analysis of gramicidin S analogues with (E)-alkene peptide isosteres

31 October 2018

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12 December 2020

Methyl- and (Trifluoromethyl)alkene Peptide Isosteres: Synthesis and Evaluation of Their Potential as beta-Turn Promoters and Peptide Mimetics

1 reference

12 December 2020

Synthesis of Sulfur-Containing Olefinic Peptide Mimetic Farnesyl Transferase Inhibitors Using the Nozaki-Hiyama-Kishi Reaction and Cuprate S(N)2' Displacements

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12 December 2020

The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability

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12 December 2020

Dimethylzinc-mediated additions of alkenylzirconocenes to aldimines. New methodologies for allylic amine and C-cyclopropylalkylamine syntheses

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12 December 2020

A new bicyclic dipeptide isostere with pyrrolizidinone skeleton

1 reference

12 December 2020

Gramicidin S is active against both gram-positive and gram-negative bacteria

1 reference

12 December 2020

Identifiers

DOI

10.1021/OL0617704

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24 July 2017

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24 July 2017

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