Engineering novel binding proteins from nonimmunoglobulin domains (Q33224761)

24 July 2017

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title

Engineering novel binding proteins from nonimmunoglobulin domains (English)

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24 July 2017

Andreas Plückthun

3

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author name string

H Kaspar Binz

series ordinal

1

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24 July 2017

Patrick Amstutz

series ordinal

2

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24 July 2017

publication date

1 October 2005

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24 July 2017

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24 July 2017

volume

23

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24 July 2017

issue

10

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24 July 2017

page(s)

1257-1268

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Engineered antibody fragments and the rise of single domains

24 July 2017

cites work

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Stability engineering of antibody single-chain Fv fragments

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Antibody-cytokine fusion proteins: harnessing the combined power of cytokines and antibodies for cancer therapy

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Peptide-small molecule hybrids via orthogonal deprotection-chemoselective conjugation to cysteine-anchored scaffolds. A model study

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Affinity maturation of a Taq DNA polymerase specific affibody by helix shuffling

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7 January 2021

Tumor targeting of mono-, di-, and tetravalent anti-p185(HER-2) miniantibodies multimerized by self-associating peptides

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DX-88 and HAE: a developmental perspective

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7 January 2021

PEGylated antibodies and antibody fragments for improved therapy: a review

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Towards in silico prediction of immunogenic epitopes

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Combining computer algorithms with experimental approaches permits the rapid and accurate identification of T cell epitopes from defined antigens

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Antibodies in diagnostics - from immunoassays to protein chips

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Affibody-beta-galactosidase immunoconjugates produced as soluble fusion proteins in the Escherichia coli cytosol

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TEM-1 beta-lactamase as a scaffold for protein recognition and assay

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7 January 2021

Dual labeling of a binding protein allows for specific fluorescence detection of native protein

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7 January 2021

Green fluorescent protein as a scaffold for intracellular presentation of peptides

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Knowledge-based design of reagentless fluorescent biosensors from recombinant antibodies

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7 January 2021

Inclusion of a non-immunoglobulin binding protein in two-site ELISA for quantification of human serum proteins without interference by heterophilic serum antibodies

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7 January 2021

Tumor cell targeted gene delivery by adenovirus 5 vectors carrying knobless fibers with antibody-binding domains.

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7 January 2021

Strategies for targeting protein therapeutics to selected tissues and cells

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Molecular biology. RNAi shows cracks in its armor

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Redox state of single chain Fv fragments targeted to the endoplasmic reticulum, cytosol and mitochondria

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7 January 2021

Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering

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7 January 2021

Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor

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7 January 2021

Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins

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7 January 2021

Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans

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7 January 2021

Gating the selectivity filter in ClC chloride channels

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7 January 2021

Structural basis for recognition by an in vitro evolved affibody

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7 January 2021

High-affinity binders selected from designed ankyrin repeat protein libraries

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7 January 2021

Allosteric inhibition of aminoglycoside phosphotransferase by a designed ankyrin repeat protein

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7 January 2021

Improving the tolerance of a protein a analogue to repeated alkaline exposures using a bypass mutagenesis approach

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7 January 2021

Ligands selected from combinatorial libraries of protein A for use in affinity capture of apolipoprotein A-1M and taq DNA polymerase

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7 January 2021

Self-immobilizing recombinant antibody fragments for immunoaffinity chromatography: generic, parallel, and scalable protein purification

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7 January 2021

Initial sequencing and analysis of the human genome

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7 January 2021

The fibronectin type III domain as a scaffold for novel binding proteins

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7 January 2021

A combinatorial library of an alpha-helical bacterial receptor domain

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7 January 2021

Recombinant human factor VIII-specific affinity ligands selected from phage-displayed combinatorial libraries of protein A.

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7 January 2021

Anti-idiotypic protein domains selected from protein A-based affibody libraries

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7 January 2021

Site-specific and reversible anchoring of active proteins onto cellulose using a cellulosome-like complex

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7 January 2021

Human immunoglobulin A (IgA)-specific ligands from combinatorial engineering of protein A.

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7 January 2021

An in vitro selected binding protein (affibody) shows conformation-dependent recognition of the respiratory syncytial virus (RSV) G protein

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7 January 2021

Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain

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7 January 2021

Lipocalins as a scaffold

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7 January 2021

Small antibody-like proteins with prescribed ligand specificities derived from the lipocalin fold.

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7 January 2021

Generation of anticalins with specificity for a nonsymmetric phthalic acid ester

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7 January 2021

A novel type of receptor protein, based on the lipocalin scaffold, with specificity for digoxigenin

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7 January 2021

Construction of an artificial receptor protein ("anticalin") based on the human apolipoprotein D.

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7 January 2021

A novel strategy to design binding molecules harnessing the modular nature of repeat proteins.

1 reference

7 January 2021

Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins.

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7 January 2021

Designed to be stable: crystal structure of a consensus ankyrin repeat protein

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7 January 2021

Structure, function and evolution of plant disease resistance genes

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7 January 2021

Innate immune recognition

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7 January 2021

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

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7 January 2021

Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

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7 January 2021

A repertoire library that allows the selection of synthetic SH2s with altered binding specificities

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7 January 2021

In vitro evolution of recognition specificity mediated by SH3 domains reveals target recognition rules

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7 January 2021

Capacity of simian immunodeficiency virus strain mac Nef for high-affinity Src homology 3 (SH3) binding revealed by ligand-tailored SH3 domains

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7 January 2021

Mutagenesis and selection of PDZ domains that bind new protein targets.

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7 January 2021

Random mutagenesis of PDZOmi domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis

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7 January 2021

Directed evolution of PDZ variants to generate high-affinity detection reagents

1 reference

7 January 2021

Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins.

1 reference

7 January 2021

Scorpion toxins as natural scaffolds for protein engineering

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7 January 2021

Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes

1 reference

7 January 2021

New binding specificities derived from Min-23, a small cystine-stabilized peptidic scaffold

1 reference

7 January 2021

Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth

1 reference

7 January 2021

Engineering of a macromolecular scaffold to develop specific protease inhibitors

1 reference

7 January 2021

A synthetic IgG-binding domain based on staphylococcal protein A.

1 reference

7 January 2021

Directed evolution of a protein: selection of potent neutrophil elastase inhibitors displayed on M13 fusion phage

1 reference

7 January 2021

Evolutionary molecular engineering by random elongation mutagenesis

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7 January 2021

In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

1 reference

7 January 2021

Directed evolution of a stable scaffold for T-cell receptor engineering.

1 reference

7 January 2021

Directed evolution of a single-chain class II MHC product by yeast display

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7 January 2021

Directed evolution of human T-cell receptors with picomolar affinities by phage display

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7 January 2021

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides

1 reference

7 January 2021

Consensus-derived structural determinants of the ankyrin repeat motif

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7 January 2021

Designing repeat proteins: modular leucine-rich repeat protein libraries based on the mammalian ribonuclease inhibitor family.

1 reference

7 January 2021

Design of Stable α-Helical Arrays from an Idealized TPR Motif

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7 January 2021

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

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7 January 2021

Trinucleotide phosphoramidites: ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis

1 reference

7 January 2021

Crystallographic analysis of an "anticalin" with tailored specificity for fluorescein reveals high structural plasticity of the lipocalin loop region

1 reference

7 January 2021

Structural mechanism of specific ligand recognition by a lipocalin tailored for the complexation of digoxigenin

1 reference

7 January 2021

Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface

1 reference

7 January 2021

Selection of functional T cell receptor mutants from a yeast surface-display library

1 reference

7 January 2021

In vitro selection and evolution of functional proteins by using ribosome display

1 reference

7 January 2021

An in vitro polysome display system for identifying ligands from very large peptide libraries

1 reference

7 January 2021

In vitro display technologies: novel developments and applications

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7 January 2021

RNA-peptide fusions for the in vitro selection of peptides and proteins

1 reference

7 January 2021

In-vitro protein evolution by ribosome display and mRNA display

1 reference

7 January 2021

Identification of epitope-like consensus motifs using mRNA display

1 reference

7 January 2021

Display of passenger proteins on the surface of Escherichia coli K-12 by the enterohemorrhagic E. coli intimin EaeA.

1 reference

7 January 2021

Display of beta-lactamase on the Escherichia coli surface: outer membrane phenotypes conferred by Lpp'-OmpA'-beta-lactamase fusions.

1 reference

7 January 2021

Display of proteins on bacteria

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7 January 2021

Rapid isolation of high-affinity protein binding peptides using bacterial display

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7 January 2021

Covalent DNA display as a novel tool for directed evolution of proteins in vitro

1 reference

7 January 2021

CIS display: In vitro selection of peptides from libraries of protein-DNA complexes

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7 January 2021

Covalent antibody display--an in vitro antibody-DNA library selection system

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7 January 2021

An in vivo library-versus-library selection of optimized protein-protein interactions

1 reference

7 January 2021

Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactions

1 reference

7 January 2021

Split ubiquitin as a sensor of protein interactions in vivo

1 reference

7 January 2021

A bacterial two-hybrid system based on a reconstituted signal transduction pathway

1 reference

7 January 2021

Monitoring protein-protein interactions in intact eukaryotic cells by beta-galactosidase complementation

1 reference

7 January 2021

Genetic selection of peptide inhibitors of biological pathways.

1 reference

7 January 2021

Isolation of high affinity human antibodies directly from large synthetic repertoires.

1 reference

7 January 2021

Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library

1 reference

7 January 2021

Intracellular antibodies for proteomics

1 reference

7 January 2021

A conformationally homogeneous combinatorial peptide library.

1 reference

7 January 2021

Highly effective protease inhibitors from variants of human pancreatic secretory trypsin inhibitor (hPSTI): an assessment of 3-D structure-based protein design

1 reference

7 January 2021

Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel binding ligands

1 reference

7 January 2021

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

7 January 2021

Peptide aptamers: exchange of the thioredoxin-A scaffold by alternative platform proteins and its influence on target protein binding

1 reference

7 January 2021

Design of bioelectronic interfaces by exploiting hinge-bending motions in proteins

1 reference

7 January 2021

Computational design of receptor and sensor proteins with novel functions

1 reference

7 January 2021

Conversion of a maltose receptor into a zinc biosensor by computational design

1 reference

7 January 2021

Tendamistat as a scaffold for conformationally constrained phage peptide libraries

1 reference

7 January 2021

In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein.

1 reference

7 January 2021

Affinity transfer by CDR grafting on a nonimmunoglobulin scaffold

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7 January 2021

A carbohydrate binding module as a diversity-carrying scaffold.

1 reference

7 January 2021

Directed evolution of protein inhibitors of DNA-nucleases by in vitro compartmentalization (IVC) and nano-droplet delivery

1 reference

7 January 2021

Alpha-helically constrained phage display library

1 reference

7 January 2021

A miniprotein scaffold used to assemble the polyproline II binding epitope recognized by SH3 domains.

1 reference

7 January 2021

Molecular Recognition of Protein Surfaces: High Affinity Ligands for the CBP KIX Domain

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7 January 2021

Protein grafting of an HIV-1-inhibiting epitope

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7 January 2021

Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2.

1 reference

7 January 2021

Engineering a protein scaffold from a PHD finger

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7 January 2021

Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level

1 reference

7 January 2021

A human pancreatic secretory trypsin inhibitor presenting a hypervariable highly constrained epitope via monovalent phagemid display

1 reference

7 January 2021

Obtaining a family of high-affinity, high-specificity protein inhibitors of plasmin and plasma kallikrein

1 reference

7 January 2021

Functional phage display of leech-derived tryptase inhibitor (LDTI): construction of a library and selection of thrombin inhibitors

1 reference

7 January 2021

Functional expression on bacteriophage of the mustard trypsin inhibitor MTI-2.

1 reference

7 January 2021

A conformation-constrained peptide library based on insect defensin A.

1 reference

7 January 2021

The cystine knot of a squash-type protease inhibitor as a structural scaffold for Escherichia coli cell surface display of conformationally constrained peptides

1 reference

7 January 2021

Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage

1 reference

7 January 2021

Alpha-amylase inhibitors selected from a combinatorial library of a cellulose binding domain scaffold

1 reference

7 January 2021

Alternate protein frameworks for molecular recognition

1 reference

7 January 2021

Mutational analysis of affinity and selectivity of kringle-tetranectin interaction. Grafting novel kringle affinity ontp the trtranectin lectin scaffold

1 reference

7 January 2021

Yeast surface display for screening combinatorial polypeptide libraries

1 reference

7 January 2021

Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation

1 reference

7 January 2021

Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals

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7 January 2021

MOLMOL: a program for display and analysis of macromolecular structures

1 reference

7 January 2021

Domain antibodies: proteins for therapy

1 reference

7 January 2021

Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries

1 reference

7 January 2021

Identifiers

DOI

10.1038/NBT1127

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24 July 2017

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