Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness (Q33208695)

23 July 2017

title

Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness (English)

1 reference

23 July 2017

main subject

African trypanosomiasis

1 reference

Terry K Smith

1

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23 July 2017

Arthur Crossman

series ordinal

2

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23 July 2017

John S Brimacombe

series ordinal

3

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23 July 2017

Michael A J Ferguson

series ordinal

4

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23 July 2017

language of work or name

English

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publication date

4 November 2004

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23 July 2017

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23 July 2017

volume

23

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23 July 2017

issue

23

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23 July 2017

page(s)

4701-4708

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Inhibitors of glycosyl-phosphatidylinositol anchor biosynthesis

23 July 2017

cites work

1 reference

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Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8

21 June 2018

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Prodrugs of biologically active phosphate esters

21 June 2018

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Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite.

21 June 2018

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Purification, cloning and characterization of a GPI inositol deacylase from Trypanosoma brucei

21 June 2018

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Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.

21 June 2018

1 reference

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Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis

21 June 2018

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Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Parasite and mammalian GPI biosynthetic pathways can be distinguished using synthetic substrate analogues

21 June 2018

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Substrate specificity of the N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol membrane anchor biosynthesis in African trypanosomes and human cells.

21 June 2018

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21 June 2018

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Substrate specificity of the dolichol phosphate mannose: glucosaminyl phosphatidylinositol alpha1-4-mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes

21 June 2018

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Myristate exchange on the Trypanosoma brucei variant surface glycoprotein

21 June 2018

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Toxicity of myristic acid analogs toward African trypanosomes

21 June 2018

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The role of inositol acylation and inositol deacylation in GPI biosynthesis in Trypanosoma brucei.

21 June 2018

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Phenylmethanesulphonyl fluoride inhibits GPI anchor biosynthesis in the African trypanosome

21 June 2018

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An analog of myristic acid with selective toxicity for African trypanosomes

21 June 2018

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Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine

21 June 2018

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Further probing of the substrate specificities and inhibition of enzymes involved at an early stage of glycosylphosphatidylinositol (GPI) biosynthesis

21 June 2018

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Deletion of the GPIdeAc gene alters the location and fate of glycosylphosphatidylinositol precursors in Trypanosoma brucei.

21 January 2018

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A novel glycosylphosphatidylinositol in African trypanosomes. A possible catabolic intermediate

21 January 2018

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Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate

21 January 2018

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Specialized fatty acid synthesis in African trypanosomes: myristate for GPI anchors

21 January 2018

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Specificities of enzymes of glycosylphosphatidylinositol biosynthesis in Trypanosoma brucei and HeLa cells

21 January 2018

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The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodeling in African trypanosomes

21 January 2018

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Parasite glycoconjugates. Part 1. The synthesis of some early and related intermediates in the biosynthetic pathway of glycosyl-phosphatidylinositol membrane anchors

31 October 2018

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Synthesis of some second-generation substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors

21 January 2018

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Parasite-Specific Inhibition of the Glycosylphosphatidylinositol Biosynthetic Pathway by Stereoisomeric Substrate Analogues†

21 January 2018

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The mechanism of inhibition of glycosylphosphatidylinositol anchor biosynthesis in Trypanosoma brucei by mannosamine

21 January 2018

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Biologically reversible phosphate-protective groups

10 December 2018

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12 December 2020

A novel pathway for glycan assembly: biosynthesis of the glycosyl-phosphatidylinositol anchor of the trypanosome variant surface glycoprotein

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12 December 2020

Fatty acid remodeling: A novel reaction sequence in the biosynthesis of trypanosome glycosyl phosphatidylinositol membrane anchors

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12 December 2020

Characterization of abnormal free glycophosphatidylinositols accumulating in mutant lymphoma cells of classes B, E, F, and H

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.EMBOJ.7600456

1 reference

23 July 2017

1 reference

23 July 2017

1 reference