Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology. (Q33204952)

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30 December 2019

title

Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology (English)

1 reference

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30 December 2019

0 references

4

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30 December 2019

9

M Flint Beal

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30 December 2019

11

Bruce S Kristal

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30 December 2019

author name string

Irina G Stavrovskaya

1

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30 December 2019

Malini V Narayanan

2

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30 December 2019

Wenhua Zhang

3

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30 December 2019

Jill Heemskerk

5

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30 December 2019

S Stanley Young

6

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30 December 2019

John P Blass

7

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30 December 2019

Abraham M Brown

8

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30 December 2019

Robert M Friedlander

10

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language of work or name

English

0 references

publication date

1 July 2004

1 reference

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Journal of Experimental Medicine

30 December 2019

published in

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30 December 2019

volume

200

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30 December 2019

issue

2

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30 December 2019

page(s)

211-222

1 reference

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A key role for TRPM7 channels in anoxic neuronal death

30 December 2019

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The mitochondrion in apoptosis: how Pandora's box opens

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21 June 2018

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Bid acts on the permeability transition pore complex to induce apoptosis

21 June 2018

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Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes

21 June 2018

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21 June 2018

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M11L: a novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes

21 June 2018

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The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore

21 June 2018

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21 June 2018

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A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Mitochondrial Permeability Transition in the Central Nervous System: Induction by Calcium Cycling‐Dependent and ‐Independent Pathways

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21 June 2018

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Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2

21 June 2018

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Release of cytochrome c from liver mitochondria during permeability transition.

21 June 2018

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Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects

21 June 2018

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Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia

21 June 2018

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Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

21 June 2018

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Mitochondrial permeability transition is a central coordinating event of apoptosis

21 June 2018

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Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

21 June 2018

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Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochondrial permeability transition

21 June 2018

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The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain

21 June 2018

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Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Phenothiazines reduce ischemic damage to the central nervous system

21 June 2018

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Protective effects of serotonin reuptake inhibitors, citalopram and clomipramine, against hippocampal CA1 neuronal damage following transient ischemia in the gerbil

21 June 2018

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21 June 2018

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Effects of ketanserin and mianserin on delayed neuronal death induced by cerebral ischemia in Mongolian gerbils

21 June 2018

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Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion

21 June 2018

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Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents

21 January 2018

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Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

21 January 2018

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Differences in the activation of the mitochondrial permeability transition among brain regions in the rat correlate with selective vulnerability

21 January 2018

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Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver

21 January 2018

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Reduced activity of the pyruvate dehydrogenase complex but not cytochrome c oxidase is associated with neuronal loss in the striatum following short-term forebrain ischemia

21 January 2018

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Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice

21 January 2018

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Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury

21 January 2018

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21 January 2018

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A semiautomated method for measuring brain infarct volume.

21 January 2018

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Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.

21 January 2018

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Cyclosporin A and its nonimmunosuppressive analogue N-Me-Val-4-cyclosporin A mitigate glucose/oxygen deprivation-induced damage to rat cultured hippocampal neurons

21 January 2018

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Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation

21 January 2018

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Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization

21 January 2018

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The neuroprotective and hypothermic effect of GYKI-52466, a non-competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-antagonist on histological and behavioural variables in the gerbil global ischemia model.

21 January 2018

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The phospholipase A2 inhibitor, quinacrine, reduces infarct size in rats after transient middle cerebral artery occlusion

21 January 2018

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Protection by prostaglandins from glutamate toxicity in cortical neurons

21 January 2018

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Protective effect of the antipsychotic drug zotepine on dizocilpine-induced neuropathological changes in rat retrosplenial cortex.

21 January 2018

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Exogenous smac induces competence and permits caspase activation in sympathetic neurons.

21 January 2018

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31 October 2018

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Mitochondria control ampa/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells.

31 October 2018

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Inhibition of glutamate-induced mitochondrial depolarization by tamoxifen in cultured neurons.

31 October 2018

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Efficacy of clozapine compared with other antipsychotics in preventing NMDA-antagonist neurotoxicity.

31 October 2018

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Flow cytometric kinetic measurements of neutrophil phospholipase A activation

31 October 2018

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Teaching old drugs new tricks. Meeting of the Neurodegeneration Drug Screening Consortium, 7-8 April 2002, Washington, DC, USA

31 October 2018

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12 December 2020

Functional and electrophysiological effects of quinacrine on the response of ventricular tissues to hypoxia and reoxygenation

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12 December 2020

Pharmacologic protection of perfused rat heart against global ischemia

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12 December 2020

Neuroblastoma cells for testing neuroprotective drug effects

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12 December 2020

Amitriptyline prevents N-methyl-D-aspartate (NMDA)-induced toxicity, does not prevent NMDA-induced elevations of extracellular glutamate, but augments kainate-induced elevations of glutamate

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12 December 2020

Classification of compounds for prevention of NMDLA-induced seizures/mortality, or maximal electroshock and pentylenetetrazol seizures in mice and antagonism of MK801 binding in vitro

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12 December 2020

Ca2 antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen

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12 December 2020

Influence of some biological response modifiers on swelling of rat liver mitochondria in vitro

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12 December 2020

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

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12 December 2020

Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition

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12 December 2020

Effects of antipsychotic drugs on neurotoxicity, expression of fos-like protein and c-fos mRNA in the retrosplenial cortex after administration of dizocilpine

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12 December 2020

Cerebroprotective action of the phospholipase inhibitor quinacrine in the ischemia/reperfused gerbil hippocampus

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12 December 2020

Identifiers

DOI

10.1084/JEM.20032053

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15263028 AND SRC:MED&resulttype=core&format=json

30 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15263028 AND SRC:MED&resulttype=core&format=json

30 December 2019

PubMed publication ID

15263028

1 reference