Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome (Q33163717)

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5 March 2020

title

Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome (English)

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5 March 2020

1 reference

myelodysplastic syndrome

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inferred from title

acute myeloid leukemia

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inferred from title

author

Sridurga Mithraprabhu

3

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Peter Mollee

11

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Anthony E Dear

14

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author name string

P Tan

1

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A Wei

2

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N Cummings

4

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H B Liu

5

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M Perugini

6

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K Reed

7

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S Avery

8

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S Patil

9

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P Walker

10

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A Grigg

12

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R D'Andrea

13

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A Spencer

15

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publication date

10 January 2014

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volume

4

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page(s)

e170

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Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies.

5 March 2020

cites work

1 reference

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HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML

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Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.

28 July 2018

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28 July 2018

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Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

28 July 2018

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Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes

28 July 2018

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Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

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Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

28 July 2018

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

28 July 2018

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International scoring system for evaluating prognosis in myelodysplastic syndromes

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The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology

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5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin

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Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia

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21 January 2018

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21 January 2018

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GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations

21 January 2018

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21 January 2018

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12 December 2020

Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome

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12 December 2020

Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia

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Azacitidine for the treatment of patients with acute myeloid leukemia: report of 82 patients enrolled in an Italian Compassionate Program

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A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment

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Identifiers

DOI

10.1038/BCJ.2013.68

1 reference

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Dimensions Publication ID

5 March 2020

0 references

1 reference

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5 March 2020

PubMed publication ID

24413064

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