Adenosine deaminase: functional implications and different classes of inhibitors (Q32063453)

6 July 2017

1 reference

title

Adenosine deaminase: functional implications and different classes of inhibitors (English)

1 reference

6 July 2017

E Camaioni

7

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Catia Lambertucci

object named as

C Lambertucci

3

0 references

Giulio Lupidi

object named as

G Lupidi

4

0 references

Stefano Costanzi

object named as

S Costanzi

2

0 references

author name string

G Cristalli

1

1 reference

6 July 2017

S Vittori

5

1 reference

6 July 2017

R Volpini

6

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6 July 2017

publication date

1 March 2001

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Medicinal Research Reviews

6 July 2017

published in

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6 July 2017

volume

21

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6 July 2017

issue

2

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6 July 2017

page(s)

105-128

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The deaminases of adenosine and adenylic acid in blood and tissues

6 July 2017

cites work

1 reference

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Purification, characterization and radioimmunoassay of adenosine deaminase from human leukaemic granulocytes

21 January 2018

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Purification and partial characterization of brain adenosine deaminase: inhibition by purine compounds and by drugs

21 January 2018

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Deduced amino acid sequence of Escherichia coli adenosine deaminase reveals evolutionarily conserved amino acid residues: implications for catalytic function

21 January 2018

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Primary structure of bovine adenosine deaminase

21 January 2018

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The crystal structure of urease from Klebsiella aerogenes

21 January 2018

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Adenosine deaminase from Saccharomyces cerevisiae: kinetics and interaction with transition and ground state inhibitors

21 January 2018

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Two different hepatic adenosine deaminases in the chicken

21 January 2018

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Adenosine deaminase activity in chronic lymphocytic leukemia. Relationship to B- and T-cell subpopulations

21 January 2018

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Sequence of human adenosine deaminase cDNA including the coding region and a small intron

21 January 2018

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Complete sequence and structure of the gene for human adenosine deaminase

21 January 2018

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Structural and functional analysis of the murine adenosine deaminase gene

21 January 2018

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A 43.5 kb segment of yeast chromosome XIV, which contains MFA2, MEP2, CAP/SRV2, NAM9, FKB1/FPR1/RBP1, MOM22 and CPT1, predicts an adenosine deaminase gene and 14 new open reading frames

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Gene organization in the ada-rplL region of Streptomyces virginiae

21 January 2018

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https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations

21 January 2018

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https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water

21 January 2018

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Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase

21 January 2018

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https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Localization of purine metabolizing enzymes in bovine brain microvessel endothelial cells: an enzymatic blood-brain barrier for dideoxynucleosides?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Cell surface adenosine deaminase: much more than an ectoenzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Enzymatic and extraenzymatic role of ecto-adenosine deaminase in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Presence of adenosine deaminase on the surface of mononuclear blood cells: immunochemical localization using light and electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Direct association of adenosine deaminase with a T cell activation antigen, CD26

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Dipeptidyl-peptidase IV/CD26 on T cells: analysis of an alternative T-cell activation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

The CP-I subunit of adenosine deaminase complexing protein from calf kidney is identical to human, mouse, and rat dipeptidyl peptidase IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Dipeptidyl-peptidase IV-beta--further characterization and comparison to dipeptidyl-peptidase IV activity of CD26.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase increases release of excitatory amino acids through a mechanism independent of adenosine depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Theoretical study of inhibition of adenosine deaminase by (8R)-coformycin and (8R)-deoxycoformycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

A quantum chemical study of the enzymatic deamination of benzoadenine derivatives. A theoretical model of the interactions occurring between nucleosides and the active site of adenosine deaminase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

The role of divalent cations in structure and function of murine adenosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Purine nucleoside metabolism in the erythrocytes of patients with adenosine deaminase deficiency and severe combined immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Purine metabolism in adenosine deaminase deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase deficiency: molecular basis and recent developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Metabolic and immunologic consequences of limited adenosine deaminase expression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine–deaminase–deficient mice die perinatally and exhibit liver–cell degeneration, atelectasis and small intestinal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Structure of Adenosine Deaminase mRNAs From Normal and Adenosine Deaminase-Deficient Human Cell Lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Isolation of cDNA clones for human adenosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Cloning of cDNA sequences of human adenosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase (ADA) deficiency in cells derived from humans with severe combined immunodeficiency is due to an aberration of the ADA protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Cloning of human adenosine deaminase cDNA and expression in mouse cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Identification of a point mutation resulting in a heat-labile adenosine deaminase (ADA) in two unrelated children with partial ADA deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Identification of two new missense mutations (R156C and S291L) in two ADA− SCID patients unusual for response to therapy with partial exchange transfusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Novel splicing, missense, and deletion mutations in seven adenosine deaminase-deficient patients with late/delayed onset of combined immunodeficiency disease. Contribution of genotype to phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Homozygosity for a missense mutation (G20R) associated with neonatal onset adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Three new adenosine deaminase mutations that define a splicing enhancer and cause severe and partial phenotypes: implications for evolution of a CpG hotspot and expression of a transduced ADA cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5′ splice site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Two newly identified mutations (Thr233Ile and Leu152Met) in partially adenosine deaminase-deficient (ADA - ) individuals that result in differing biochemical and metabolic phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Clinical expression, genetics and therapy of adenosine deaminase (ADA) deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Modelling of purine nucleoside metabolism during mouse embryonic development: relative routes of adenosine, deoxyadenosine, and deoxyguanosine metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

An intron 1 regulatory region from the murine adenosine deaminase gene can activate heterologous promoters for ubiquitous expression in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Ontogeny of adenosine deaminase in the mouse decidua and placenta: immunolocalization and embryo transfer studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Coordinate developmental regulation of purine catabolic enzyme expression in gastrointestinal and postimplantation reproductive tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine levels in the postimplantation mouse uterus: quantitation by HPLC-fluorometric detection and spatiotemporal regulation by 5'-nucleotidase and adenosine deaminase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Significance of adenosine deaminase activity and its isoenzymes in tuberculous effusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine Deaminase Activity in the Aetiological Diagnosis of Community-acquired Pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Correlation of adenosine deaminase activity with cell surface markers in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase and adenosine kinase in rat hepatomas and kidney tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Elevated erythrocyte adenosine deaminase activity in congenital hypoplastic anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Serum and synovial fluid adenosine deaminase activity in patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase deficiency: disappearance of adenine deoxynucleotides from a patient's erythrocytes after successful marrow transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Gene therapy for severe combined immunodeficiency caused by adenosine deaminase deficiency: improved retroviral vectors for clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Deoxycoformycin in the treatment of leukemias and lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase inhibitors: their role in chemotherapy and immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase in herpes simplex virus induced corneal stromal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Effects of adenosine deaminase inhibitor 2'-deoxycoformycin on the repair and expression of potentially lethal damage sensitive to beta-araA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Effects of N6-cyclopentyl adenosine and 8-cyclopentyl-1,3-dipropylxanthine on N-methyl-D-aspartate induced seizures in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Increases in interstitial adenosine and cerebral blood flow with inhibition of adenosine kinase and adenosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Co-administration of adenosine kinase and deaminase inhibitors produces supra-additive potentiation of N-methyl-D-aspartate-evoked adenosine formation in cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Harnessing an endogenous cardioprotective mechanism: cellular sources and sites of action of adenosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Effects of adenosine deaminase inhibition on blood pressure in old spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Tight-binding inhibitors--IV. Inhibition of adenosine deaminases by various inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Study on the inhibition of adenosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase inhibitors. Synthesis and biological evaluation of ( /-)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d] [1,3]diazepin-8-ol and some selected C-5 homologues of pentostatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

The biochemical pharmacology of (2'-R)-chloropentostatin, a novel inhibitor of adenosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Inhibition of adenosine deaminase from several sources by deaza derivatives of adenosine and EHNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Purine and 1-deazapurine ribonucleosides and deoxyribonucleosides: synthesis and biological activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Synthesis and biological evaluation of N6-cycloalkyl derivatives of 1-deazaadenine nucleosides: a new class of anti-human immunodeficiency virus agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase: viscosity studies and the mechanism of binding of substrate and of ground- and transition-state analogue inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase inhibitors. Synthesis and biological activity of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

High Levels of Adenosine Deaminase in Patients with Aseptic Meningitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

The correlation of adenosine deaminase and purine nucleoside phosphorylase activities in human lymphocytes subpopulations and in various lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase in body fluids: A useful diagnostic tool in tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adenosine deaminase in rodent median eminence: detection by antibody to the mouse enzyme and co-localization with adenosine deaminase-complexing protein (CD26)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

Adechlorin, a new adenosine deaminase inhibitor containing chlorine production, isolation and properties

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.38.1008

Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings. Taxonomy, production and enzyme inhibition.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.39.1219

Identifiers

DOI

10.1002/1098-1128(200103)21:2<105::AID-MED1002>3.0.CO;2-U

1 reference

6 July 2017

1 reference