Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction (Q31146882)

11 September 2017

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction (English)

1 reference

11 September 2017

0 references

Aref Zayed

2

0 references

author name string

Kuresh A Youdim

1

1 reference

11 September 2017

Maurice Dickins

3

1 reference

11 September 2017

Alex Phipps

4

1 reference

11 September 2017

Michelle Griffiths

5

1 reference

11 September 2017

Amanda Darekar

6

1 reference

11 September 2017

Ruth Hyland

7

1 reference

11 September 2017

Odette Fahmi

8

1 reference

11 September 2017

Susan Hurst

9

1 reference

11 September 2017

David R Plowchalk

10

1 reference

11 September 2017

Jack Cook

11

1 reference

11 September 2017

Feng Guo

12

1 reference

11 September 2017

R Scott Obach

13

1 reference

11 September 2017

language of work or name

English

0 references

publication date

14 February 2008

1 reference

British Journal of Clinical Pharmacology

11 September 2017

1 reference

11 September 2017

65

1 reference

11 September 2017

5

1 reference

11 September 2017

680-692

1 reference

Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Approach to the prediction of the contribution of major cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Prediction of pharmacokinetics and drug-drug interactions from in vitro metabolism data

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

The use of pharmacokinetic and pharmacodynamic data in the assessment of drug safety in early drug development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

An evaluation of the in vitro metabolism data for predicting the clearance and drug-drug interaction potential of CYP2C9 substrates

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expressi

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

The use of in vitro methods to predict in vivo pharmacokinetics and drug interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111/J.1365-2125.2007.03070.X

Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scaling

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111/J.1365-2125.2007.03070.X

Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2432478

Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential

31 October 2018

1 reference

12 December 2020

Predicting drug pharmacokinetics in humans from in vitro metabolism studies

1 reference

12 December 2020

Cytochrome P450 3A expression and activity in the human small intestine

1 reference

12 December 2020

Minimizing polymorphic metabolism in drug discovery: evaluation of the utility of in vitro methods for predicting pharmacokinetic consequences associated with CYP2D6 metabolism

1 reference

12 December 2020

'In silico' simulations to assess the 'in vivo' consequences of 'in vitro' metabolic drug-drug interactions

1 reference

12 December 2020

10.1111/J.1365-2125.2007.03070.X

Identifiers

DOI

1 reference

11 September 2017

1 reference

11 September 2017

PubMed publication ID

18279465

1 reference