Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities. (Q30871433)

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English	Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.	scientific article

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4 February 2020

Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities (English)

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4 February 2020

phosphorylation

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4 February 2020

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Steven Fletcher

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4 February 2020

Jagdeep Singh

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Xiaolei Zhang

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Peibin Yue

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Brent D G Page

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Sumaiya Sharmeen

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4 February 2020

Vijay M Shahani

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Wei Zhao

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James Turkson

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Patrick T Gunning

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1 August 2009

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4 February 2020

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4 February 2020

10

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4 February 2020

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4 February 2020

1959-1964

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4 February 2020

Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation

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Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders

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21 June 2018

Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein

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21 June 2018

Signal transducers and activators of transcription as targets for small organic molecules

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21 June 2018

Protein-protein interaction inhibitors: small molecules from screening techniques

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PTP1B as a drug target: recent developments in PTP1B inhibitor discovery

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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

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Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains

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Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

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21 June 2018

Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics

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21 June 2018

Targeting protein-protein interactions by rational design: mimicry of protein surfaces

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DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation

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Protein surface recognition and proteomimetics: mimics of protein surface structure and function

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21 June 2018

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

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Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity.

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21 June 2018

Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells

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Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention

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21 June 2018

Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

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21 June 2018

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

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21 June 2018

STATs in oncogenesis

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21 June 2018

Three-dimensional structure of the Stat3beta homodimer bound to DNA

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21 June 2018

STATs and Gene Regulation

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The JAK-STAT pathway: summary of initial studies and recent advances.

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Identification of a high-affinity phosphopeptide inhibitor of Stat3.

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Validating Stat3 in cancer therapy

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Pd/C(en) catalyzed chemoselective hydrogenation in the presence of aryl nitriles

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Design and synthesis of a new, conformationally constrained, macrocyclic small-molecule inhibitor of STAT3 via 'click chemistry'

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12 December 2020

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An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects

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Targeting STAT3 in cancer: how successful are we?

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10.1002/CBIC.200900172

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4 February 2020

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