Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia (Q30848149)

18 October 2017

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia (English)

1 reference

18 October 2017

9

1 reference

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8 June 2020

author name string

K Chitta

1

1 reference

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8 June 2020

A Paulus

2

1 reference

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8 June 2020

T R Caulfield

3

1 reference

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8 June 2020

S Akhtar

4

1 reference

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8 June 2020

M-K K Blake

5

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8 June 2020

S Ailawadhi

6

1 reference

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8 June 2020

J Knight

7

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8 June 2020

M G Heckman

8

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8 June 2020

A Chanan-Khan

10

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8 June 2020

publication date

7 November 2014

1 reference

18 October 2017

1 reference

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8 June 2020

volume

4

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8 June 2020

page(s)

e260

1 reference

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

8 June 2020

copyright license

start time

1 November 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

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21 June 2018

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21 June 2018

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AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia

21 June 2018

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Direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth.

21 June 2018

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Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line

21 June 2018

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Nimbolide, a limonoid triterpene, inhibits growth of human colorectal cancer xenografts by suppressing the proinflammatory microenvironment

21 June 2018

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The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

21 June 2018

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In silico target fishing for the potential targets and molecular mechanisms of baicalein as an antiparkinsonian agent: discovery of the protective effects on NMDA receptor-mediated neurotoxicity

21 June 2018

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Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS

21 June 2018

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21 June 2018

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Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach

21 June 2018

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Development and characterization of a novel human Waldenström macroglobulinemia cell line: RPCI-WM1, Roswell Park Cancer Institute - Waldenström Macroglobulinemia 1.

21 June 2018

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Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

21 June 2018

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Inhibition of Prohormone Convertases PC1/3 and PC2 by 2,5-Dideoxystreptamine Derivatives

21 June 2018

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A Comparative Reverse Docking Strategy to Identify Potential Antineoplastic Targets of Tea Functional Components and Binding Mode

21 June 2018

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Anticancer biology of Azadirachta indica L (neem): a mini review

21 June 2018

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Examinations of tRNA Range of Motion Using Simulations of Cryo-EM Microscopy and X-Ray Data

21 June 2018

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Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP‐2/9 expression via inhibiting ERK1/2 and reducing DNA‐binding activity of NF‐κB in colon cancer cells

21 June 2018

1 reference

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Inter-ring rotation of apolipoprotein A-I protein monomers for the double-belt model using biased molecular dynamics

21 June 2018

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An inverse docking approach for identifying new potential anti-cancer targets.

21 June 2018

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Advances in the computational development of DNA methyltransferase inhibitors

21 June 2018

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Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

21 June 2018

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Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.

21 June 2018

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Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents

21 June 2018

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21 June 2018

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The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells

21 June 2018

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Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70

21 June 2018

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21 June 2018

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Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

21 June 2018

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BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells.

21 June 2018

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Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells

21 June 2018

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BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

21 June 2018

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Mitochondrial membrane permeabilization in cell death

21 June 2018

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Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica).

21 June 2018

1 reference

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

21 June 2018

1 reference

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Finding the target after screening the phenotype

21 June 2018

1 reference

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Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

21 June 2018

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Clinicopathological definition of Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia

21 June 2018

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The biochemistry of apoptosis

21 June 2018

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Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance.

21 June 2018

1 reference

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Cytotoxicity of nimbolide, epoxyazadiradione and other limonoids from neem insecticide

21 June 2018

1 reference

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Bortezomib mitigates adverse prognosis conferred by Bcl-2 overexpression in patients with relapsed/refractory multiple myeloma

21 June 2018

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BCL2 predicts survival in germinal center B-cell-like diffuse large B-cell lymphoma treated with CHOP-like therapy and rituximab

21 January 2018

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Neem leaf extract induces cell death by apoptosis and autophagy in B-chronic lymphocytic leukemia cells

21 January 2018

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The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis.

21 January 2018

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How far can virtual screening take us in drug discovery?

21 January 2018

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Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule

21 January 2018

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Motion of transfer RNA from the A/T state into the A-site using docking and simulations

21 January 2018

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Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.

21 January 2018

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Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases

21 January 2018

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The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis.

21 January 2018

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Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

21 January 2018

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Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies

21 January 2018

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Acute toxicity of nimbolide and nimbic acid in mice, rats and hamsters

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25382610

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular dynamics simulations of human DNA methyltransferase 3B with selective inhibitor nanaomycin A

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25382610

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Impact of hepatitis C on renal transplantation: a long-term study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25382610

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/BCJ.2014.74

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25382610 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

8 June 2020

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8 June 2020

PubMed publication ID

25382610

1 reference

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