TGF-beta signaling from receptors to the nucleus (Q30829255)

26 June 2017

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title

TGF-beta signaling from receptors to the nucleus (English)

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26 June 2017

A B Roberts

1

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26 June 2017

publication date

1 December 1999

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26 June 2017

published in

Microbes and Infection

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26 June 2017

volume

1

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26 June 2017

issue

15

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26 June 2017

page(s)

1265-1273

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Regulation of immune responses by TGF-beta

26 June 2017

cites work

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Smads: transcriptional activators of TGF-beta responses

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TGF-beta signal transduction

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TGF-beta signaling, Smads, and tumor suppressors

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STATs and Gene Regulation

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TGF-β signalling from cell membrane to nucleus through SMAD proteins

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Mads and Smads in TGF beta signalling

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Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1

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TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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Signal transduction by bone morphogenetic proteins

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TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

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Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

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Determinants of specificity in TGF-beta signal transduction.

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Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

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DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

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Mutations in the SMAD4/DPC4 gene in juvenile polyposis

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Characterization of functional domains within Smad4/DPC4

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Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

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Smad6 inhibits signalling by the TGF-β superfamily

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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7 January 2021

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

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7 January 2021

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

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7 January 2021

Twenty proteins containing a C-terminal SOCS box form five structural classes

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7 January 2021

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

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7 January 2021

Transforming growth factor beta1 induces nuclear export of inhibitory Smad7

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7 January 2021

SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.

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Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

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Human Smad3 and Smad4 are sequence-specific transcription activators

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7 January 2021

Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene

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7 January 2021

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

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7 January 2021

Smad4/DPC4 and Smad3 mediate transforming growth factor-beta (TGF-beta) signaling through direct binding to a novel TGF-beta-responsive element in the human plasminogen activator inhibitor-1 promoter

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7 January 2021

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer

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7 January 2021

Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein

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7 January 2021

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

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7 January 2021

Smad4 and FAST-1 in the assembly of activin-responsive factor

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7 January 2021

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

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7 January 2021

The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

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7 January 2021

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

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7 January 2021

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

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7 January 2021

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells

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7 January 2021

Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator

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7 January 2021

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

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7 January 2021

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

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7 January 2021

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

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7 January 2021

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

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7 January 2021

Smad2 role in mesoderm formation, left-right patterning and craniofacial development

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7 January 2021

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1 reference

https://api.crossref.org/works/10.1016/S1286-4579(99)00258-0

7 January 2021

10.1016/S1286-4579(99)00258-0

Identifiers

DOI

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26 June 2017

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