Fas ligand (Q3067052)

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mammalian protein found in Homo sapiens

FasL
CD95-L
tumor necrosis factor ligand superfamily member 6
apoptosis antigen ligand
mutant tumor necrosis factor family member 6
FASLG
tumor necrosis factor ligand 1A
Fas ligand (TNF superfamily, member 6)
fas antigen ligand
CD95 ligand
apoptosis (APO-1) antigen ligand 1
APTL
fas ligand protein

Language	Label	Description	Also known as
English	Fas ligand	mammalian protein found in Homo sapiens	FasL CD95-L tumor necrosis factor ligand superfamily member 6 apoptosis antigen ligand mutant tumor necrosis factor family member 6 FASLG tumor necrosis factor ligand 1A Fas ligand (TNF superfamily, member 6) fas antigen ligand CD95 ligand apoptosis (APO-1) antigen ligand 1 APTL fas ligand protein

Statements

1 reference

13 November 2019

UniProt protein ID

tumor necrosis factor ligand superfamily member 6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48023

Tumour necrosis factor-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48023

Tumour necrosis factor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tumour necrosis factor, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cytokine activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

protein binding

determination method or standard

12 references

9 May 2019

The role of receptor internalization in CD95 signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

A type III effector antagonizes death receptor signalling during bacterial gut infection

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

signaling receptor binding

determination method or standard

1 reference

9 May 2019

Human Fas ligand: gene structure, chromosomal location and species specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

death receptor binding

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

integral component of membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

cytoplasmic vesicle lumen

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

9 May 2019

Human Fas ligand: gene structure, chromosomal location and species specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

lysosomal lumen

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

perinuclear region of cytoplasm

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

extracellular exosome

determination method or standard

1 reference

9 May 2019

Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

external side of plasma membrane

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

biological process

T cell apoptotic process

determination method or standard

1 reference

9 May 2019

Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48023&geneProductId=UniProtKB:P48023

determination method or standard

cell-cell signaling

determination method or standard

1 reference

9 May 2019

Human Fas ligand: gene structure, chromosomal location and species specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

endosomal lumen acidification

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

1 reference

9 May 2019

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

retinal cell programmed cell death

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48023&geneProductId=UniProtKB:P48023

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

positive regulation of neuron apoptotic process

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

positive regulation of endothelial cell apoptotic process

determination method or standard

1 reference

9 May 2019

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

necroptotic signaling pathway

determination method or standard

1 reference

9 May 2019

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

immune response

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

positive regulation of cell population proliferation

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

1 reference

8 April 2019

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

negative regulation of angiogenesis

determination method or standard

1 reference

9 May 2019

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

cellular chloride ion homeostasis

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

response to growth factor

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

inflammatory cell apoptotic process

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

positive regulation of epidermal growth factor receptor signaling pathway

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

8 April 2019

Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

8 April 2019

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

signal transduction

determination method or standard

1 reference

9 May 2019

Human Fas ligand: gene structure, chromosomal location and species specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

extrinsic apoptotic signaling pathway

determination method or standard

1 reference

9 May 2019

Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

determination method or standard

1 reference

9 May 2019

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

apoptotic signaling pathway

determination method or standard

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

apoptotic process

determination method or standard

3 references

9 May 2019

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

release of sequestered calcium ion into cytosol by endoplasmic reticulum

determination method or standard

1 reference

9 May 2019

Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

regulation of signaling receptor activity

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

cytokine-mediated signaling pathway

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

extrinsic apoptotic signaling pathway via death domain receptors

determination method or standard

4 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48023

determination method or standard

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

Gene Atlas image

PBB GE FASLG 211333 s at fs.png
732 × 530; 11 KB

0 references

Tumour necrosis factor, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48023

Tumour necrosis factor domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P48023

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000356694

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000356694

ENSP00000344739

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000344739

1 reference

Freebase Data Dumps

publication date

28 October 2013

PDB structure ID

1 reference

UniProt protein ID

29 June 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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