Combinatorial biosynthesis of polyketides and nonribosomal peptides (Q30662200)

26 June 2017

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title

Combinatorial biosynthesis of polyketides and nonribosomal peptides (English)

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26 June 2017

Staunton J

1

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26 June 2017

Wilkinson B

series ordinal

2

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26 June 2017

publication date

1 April 2001

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Current Opinion in Chemical Biology

26 June 2017

published in

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26 June 2017

volume

5

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26 June 2017

issue

2

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26 June 2017

page(s)

159-164

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Genetic Contributions to Understanding Polyketide Synthases

26 June 2017

cites work

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Harnessing the biosynthetic code: combinations, permutations, and mutations

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Design and application of multimodular peptide synthetases

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Engineering broader specificity into an antibiotic-producing polyketide synthase

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Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives

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7 January 2021

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

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Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension

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7 January 2021

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Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

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A multiplasmid approach to preparing large libraries of polyketides

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Production of a novel polyketide through the construction of a hybrid polyketide synthase.

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Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases

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7 January 2021

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

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Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue

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7 January 2021

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

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Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase

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7 January 2021

Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

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7 January 2021

Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase

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7 January 2021

Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes

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7 January 2021

A chain initiation factor common to both modular and aromatic polyketide synthases

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7 January 2021

Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine

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7 January 2021

Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.

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7 January 2021

Alternative modular polyketide synthase expression controls macrolactone structure

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7 January 2021

The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases

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7 January 2021

Initiation, elongation, and termination strategies in polyketide and polypeptide antibiotic biosynthesis

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7 January 2021

Aminoacyl-CoAs as probes of condensation domain selectivity in nonribosomal peptide synthesis

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7 January 2021

Acyl-CoA hydrolysis by the high molecular weight protein 1 subunit of yersiniabactin synthetase: mutational evidence for a cascade of four acyl-enzyme intermediates during hydrolytic editing

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7 January 2021

Peptide cyclization catalysed by the thioesterase domain of tyrocidine synthetase

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7 January 2021

Rational Design of Peptide Antibiotics by Targeted Replacement of Bacterial and Fungal Domains

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7 January 2021

Construction of hybrid peptide synthetases by module and domain fusions

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7 January 2021

Dipeptide formation on engineered hybrid peptide synthetases

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7 January 2021

Construction and in vitro analysis of a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides

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7 January 2021

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

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7 January 2021

Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains

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7 January 2021

Polyketide synthase gene coupled to the peptide synthetase module involved in the biosynthesis of the cyclic heptapeptide microcystin

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7 January 2021

Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system.

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7 January 2021

The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase

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7 January 2021

The mycosubtilin synthetase of Bacillus subtilis ATCC6633: a multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase.

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7 January 2021

New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.

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7 January 2021

Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.

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7 January 2021

The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15.

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7 January 2021

Production of the antitumor drug epirubicin (4′-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius

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7 January 2021

10.1016/S1367-5931(00)00185-X

Identifiers

DOI

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26 June 2017

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