Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease (Q30658251)

10 August 2017

Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease (English)

1 reference

10 August 2017

Vineet Gupta

18

0 references

Luís F. Moita

Luis F Moita

Geanncarlo Lugo-Villarino

11

0 references

Geanncarlo Lugo

8

0 references

Changli Wei

3

Changli Wei

1 reference

10 August 2017

1

Dony Maiguel

1 reference

10 August 2017

2

Mohd Hafeez Faridi

1 reference

10 August 2017

7

Constantinos J Barth

1 reference

10 August 2017

Roberto I Vazquez-Padron

15

Roberto I Vazquez-Padron

1 reference

10 August 2017

Yoshihiro Kuwano

4

1 reference

10 August 2017

Keir M Balla

5

1 reference

10 August 2017

Dayami Hernandez

6

1 reference

10 August 2017

Mary Donnelly

9

1 reference

10 August 2017

Ali Nayer

10

1 reference

10 August 2017

Stephan Schürer

12

1 reference

10 August 2017

David Traver

13

1 reference

10 August 2017

Phillip Ruiz

14

1 reference

10 August 2017

Klaus Ley

16

1 reference

10 August 2017

Jochen Reiser

17

1 reference

10 August 2017

1 September 2011

1 reference

10 August 2017

1 reference

10 August 2017

4

1 reference

10 August 2017

189

1 reference

10 August 2017

ra57

1 reference

describes a project that uses

10 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4507414/fullTextXML

inferred from PubMed Central ID database lookup

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Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

14 July 2018

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High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding

14 July 2018

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Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes

14 July 2018

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Identification of novel agonists of the integrin CD11b/CD18.

14 July 2018

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Negative regulation of activated alpha-2 integrins during thrombopoiesis

14 July 2018

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The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A.

14 July 2018

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Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2.

14 July 2018

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Rapid leukocyte migration by integrin-independent flowing and squeezing

14 July 2018

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Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.

14 July 2018

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Getting to the site of inflammation: the leukocyte adhesion cascade updated

14 July 2018

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Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

14 July 2018

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A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18

14 July 2018

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The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18

14 July 2018

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A small molecule agonist of an integrin, alphaLbeta2.

14 July 2018

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Cost-effectiveness of coronary artery bypass grafts versus percutaneous coronary intervention for revascularization of high-risk patients

14 July 2018

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Genetic analysis of beta1 integrin "activation motifs" in mice

14 July 2018

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A transgenic zebrafish model of neutrophilic inflammation

14 July 2018

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Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment

14 July 2018

1 reference

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Importance of integrin LFA-1 deactivation for the generation of immune responses

14 July 2018

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In vivo drug discovery in the zebrafish

14 July 2018

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Targeting leukocyte integrins in human diseases

14 July 2018

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Impaired glucose homeostasis, neutrophil trafficking and function in mice lacking the glucose-6-phosphate transporter

14 July 2018

1 reference

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New insights into the structural basis of integrin activation.

14 July 2018

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Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.

14 July 2018

1 reference

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A comparison of balloon injury models of endovascular lesions in rat arteries

14 July 2018

1 reference

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Integrins: bidirectional, allosteric signaling machines

14 July 2018

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Requirement for RhoA kinase activation in leukocyte de-adhesion

14 July 2018

1 reference

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Leukocyte-endothelial interactions: clinical trials of anti-adhesion therapy

14 July 2018

1 reference

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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

14 July 2018

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An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

14 July 2018

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CD18 trials disappoint again

14 July 2018

1 reference

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Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty

14 July 2018

1 reference

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Functional analysis of the beta 2 integrins

14 July 2018

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A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1.

14 July 2018

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Two functional states of the CD11b A-domain: correlations with key features of two Mn2 -complexed crystal structures

14 July 2018

1 reference

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A mAb to the β2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits

14 July 2018

1 reference

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Role of intrinsic renal cells versus infiltrating cells in glomerular crescent formation

14 July 2018

1 reference

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A Role for Mac-1 (CDIIb/CD18) in Immune Complex–stimulated Neutrophil Function In Vivo: Mac-1 Deficiency Abrogates Sustained Fcγ Receptor–dependent Neutrophil Adhesion and Complement-dependent Proteinuria in Acute Glomerulonephritis

14 July 2018

1 reference

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Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

14 July 2018

1 reference

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A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation

14 July 2018

1 reference

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Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity

14 July 2018

1 reference

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Two conformations of the integrin A-domain (I-domain): a pathway for activation?

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding

14 July 2018

1 reference

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Inhibition of neutrophil adherence improves postischemic ventricular performance of the neonatal heart.

14 July 2018

1 reference

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Gene targeting yields a CD18-mutant mouse for study of inflammation.

14 July 2018

1 reference

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Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

14 July 2018

1 reference

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Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration.

14 July 2018

1 reference

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A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen

14 July 2018

1 reference

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Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol)

14 July 2018

1 reference

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Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Human neutrophils increase expression of C3bi as well as C3b receptors upon activation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro

14 July 2018

1 reference

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Regulated expression of Mg2 binding epitope on leukocyte integrin alpha subunits

14 July 2018

1 reference

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Structure and function of the leukocyte adhesion molecules CD11/CD18.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Occupancy of CD11b/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Inside-out integrin signalling

14 July 2018

1 reference

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Recruitment of CD11b/CD18 to the neutrophil surface and adherence-dependent cell locomotion

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Mac-1: a macrophage differentiation antigen identified by monoclonal antibody

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Leukocyte engagement of platelet glycoprotein Ibalpha via the integrin Mac-1 is critical for the biological response to vascular injury

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Mouse bone marrow contains large numbers of functionally competent neutrophils

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation

25 November 2018

1 reference

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Reconstructing Leukocyte Migration in 3D Extracellular Matrix by Time-Lapse Videomicroscopy and Computer-Assisted Tracking

25 November 2018

1 reference

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Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

The role of selectins in glomerular leukocyte recruitment in rat anti-glomerular basement membrane glomerulonephritis.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4507414

Synergistic neovascularization by mixed transplantation of early endothelial progenitor cells and late outgrowth endothelial cells: the role of angiogenic cytokines and matrix metalloproteinases

25 November 2018

1 reference

12 December 2020

Orientation chamber in chemotaxis

1 reference

12 December 2020

Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver

1 reference

12 December 2020

The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury

1 reference

12 December 2020

Does the integrin alphaA domain act as a ligand for its betaA domain?

1 reference

12 December 2020

Therapy: Targeted but not trouble-free: efalizumab and PML

1 reference

12 December 2020

Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils

1 reference

12 December 2020

PML problems loom for Rituxan

1 reference

12 December 2020

10.1126/SCISIGNAL.2001811

Identifiers

DOI

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

21900205

1 reference