Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells (Q30611441)

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English	Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

9 October 2017

Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells (English)

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Europe PubMed Central

PMC publication ID

9 October 2017

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Michael L Dustin

12

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Europe PubMed Central

PMC publication ID

9 October 2017

Steve P. Watson

13

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Europe PubMed Central

PMC publication ID

9 October 2017

Alice Y. Pollitt

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Alice Y Pollitt

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Craig E Hughes

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Steven G. Thomas

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Steven G Thomas

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David G Jackson

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David G Jackson

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Natalie S Poulter

2

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Europe PubMed Central

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9 October 2017

Eelo Gitz

3

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Europe PubMed Central

PMC publication ID

9 October 2017

Leyre Navarro-Nuñez

4

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Europe PubMed Central

PMC publication ID

9 October 2017

Ying-Jie Wang

5

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Europe PubMed Central

PMC publication ID

9 October 2017

Bernhard Nieswandt

8

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Europe PubMed Central

PMC publication ID

9 October 2017

Michael R Douglas

9

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Europe PubMed Central

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9 October 2017

Dylan M Owen

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Europe PubMed Central

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9 October 2017

language of work or name

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publication date

3 November 2014

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Europe PubMed Central

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9 October 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

9 October 2017

289

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Europe PubMed Central

PMC publication ID

9 October 2017

52

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Europe PubMed Central

PMC publication ID

9 October 2017

35695-35710

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Europe PubMed Central

PMC publication ID

9 October 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4276840/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276840

20 June 2018

CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276840

20 June 2018

Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276840

20 June 2018

Platelets in lymph vessel development and integrity

1 reference

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20 June 2018

Test samples for optimizing STORM super-resolution microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4276840

20 June 2018

Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

1 reference

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20 June 2018

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.

1 reference

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20 June 2018

Platelet ITAM signaling is critical for vascular integrity in inflammation

1 reference

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20 June 2018

A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy

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20 June 2018

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).

1 reference

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20 June 2018

Podoplanin: emerging functions in development, the immune system, and cancer

1 reference

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20 June 2018

Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.

1 reference

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20 June 2018

Improved platelet survival after cold storage by prevention of glycoprotein Ibα clustering in lipid rafts.

1 reference

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20 June 2018

Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells

1 reference

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20 June 2018

Podoplanin-expressing inflammatory macrophages activate murine platelets via CLEC-2.

1 reference

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20 June 2018

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

1 reference

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20 June 2018

Podoplanin Is Regulated by AP-1 and Promotes Platelet Aggregation and Cell Migration in Osteosarcoma

1 reference

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CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

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20 June 2018

Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling

1 reference

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PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

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A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

1 reference

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Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin

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A mouse knockout library for secreted and transmembrane proteins.

1 reference

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20 June 2018

Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

1 reference

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20 June 2018

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

1 reference

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20 June 2018

Regulation of developmental lymphangiogenesis by Syk( ) leukocytes

1 reference

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Restriction of receptor movement alters cellular response: physical force sensing by EphA2.

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Functional anatomy of T cell activation and synapse formation

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20 June 2018

The platelet receptor CLEC-2 is active as a dimer

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Renal cells activate the platelet receptor CLEC-2 through podoplanin

1 reference

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20 June 2018

Molecular analysis of the pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2.

1 reference

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20 June 2018

Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

1 reference

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The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis

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The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade

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Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

1 reference

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Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

1 reference

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A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

1 reference

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Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas

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Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

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Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells

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The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

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20 June 2018

The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.

1 reference

https://api.crossref.org/works/10.1074/JBC.M114.584284

21 January 2018

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.

1 reference

https://api.crossref.org/works/10.1074/JBC.M114.584284

21 January 2018

A distinct subset of podoplanin (gp38) expressing F4/80 macrophages mediate phagocytosis and are induced following zymosan peritonitis

1 reference

https://api.crossref.org/works/10.1074/JBC.M114.584284

21 January 2018

T1alpha/podoplanin is essential for capillary morphogenesis in lymphatic endothelial cells

1 reference

https://api.crossref.org/works/10.1074/JBC.M114.584284

21 January 2018

CLEC-2 is not required for platelet aggregation at arteriolar shear

1 reference

https://api.crossref.org/works/10.1074/JBC.M114.584284

21 January 2018

Lifeact mice for studying F-actin dynamics

1 reference

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21 January 2018

Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase

1 reference

https://api.crossref.org/works/10.1074/JBC.M114.584284

21 January 2018

PALM imaging and cluster analysis of protein heterogeneity at the cell surface

1 reference

https://api.crossref.org/works/10.1074/JBC.M114.584284

21 January 2018

Lck and the nature of the T cell receptor trigger

1 reference

https://api.crossref.org/works/10.1074/JBC.M114.584284

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1 reference

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

1 reference

https://api.crossref.org/works/10.1074/JBC.M114.584284

21 January 2018

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25368330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25368330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42

1 reference

https://pubmed.ncbi.nlm.nih.gov/25368330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studying cell-to-cell interactions: an easy method of tethering ligands on artificial membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25368330

12 December 2020

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CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/25368330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M114.584284

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

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