Structural dynamic analysis of apo and ATP-bound IRAK4 kinase (Q30584224)

19 October 2017

Structural dynamic analysis of apo and ATP-bound IRAK4 kinase (English)

1 reference

19 October 2017

Vijayakumar Gosu

1

1 reference

19 October 2017

Sangdun Choi

series ordinal

2

1 reference

19 October 2017

language of work or name

English

0 references

publication date

18 July 2014

1 reference

19 October 2017

1 reference

19 October 2017

4

1 reference

19 October 2017

5748

1 reference

Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

19 October 2017

start time

18 July 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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20 June 2018

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20 June 2018

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Therapeutic applications of nucleic acids and their analogues in Toll-like receptor signaling.

20 June 2018

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Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase

20 June 2018

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Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IκBα deficiency

20 June 2018

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Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.

20 June 2018

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Structure-function similarities between a plant receptor-like kinase and the human interleukin-1 receptor-associated kinase-4.

20 June 2018

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Protein kinases: evolution of dynamic regulatory proteins

20 June 2018

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Steady-state kinetic characterization of kinase activity and requirements for Mg2 of interleukin-1 receptor-associated kinase-4.

20 June 2018

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Global consequences of activation loop phosphorylation on protein kinase A.

20 June 2018

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IRAK-4 inhibitors for inflammation

20 June 2018

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The potential use of Toll-like receptor (TLR) agonists and antagonists as prophylactic and/or therapeutic agents

20 June 2018

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Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.

20 June 2018

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IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans

20 June 2018

1 reference

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Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity

20 June 2018

1 reference

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A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

20 June 2018

1 reference

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IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression

20 June 2018

1 reference

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Cutting Edge: IL-1 receptor-associated kinase 4 structures reveal novel features and multiple conformations

20 June 2018

1 reference

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Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper

20 June 2018

1 reference

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Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop

20 June 2018

1 reference

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Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

20 June 2018

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20 June 2018

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Conformational changes in protein loops and helices induced by post-translational phosphorylation

20 June 2018

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How does activation loop phosphorylation modulate catalytic activity in the cAMP-dependent protein kinase: a theoretical study

20 June 2018

1 reference

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Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses

20 June 2018

1 reference

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Activation of the Src family kinase Hck without SH3-linker release

20 June 2018

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Cutting edge: expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex

20 June 2018

1 reference

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Inherited disorders of human Toll-like receptor signaling: immunological implications.

20 June 2018

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Regulation of protein kinases; controlling activity through activation segment conformation

20 June 2018

1 reference

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The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling

20 June 2018

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20 June 2018

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20 June 2018

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A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient

20 June 2018

1 reference

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Toll-like receptor signalling

20 June 2018

1 reference

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Structural modes of stabilization of permissive phosphorylation sites in protein kinases: distinct strategies in Ser/Thr and Tyr kinases

20 June 2018

1 reference

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Pyogenic bacterial infections in humans with IRAK-4 deficiency

20 June 2018

1 reference

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Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

20 June 2018

1 reference

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Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family

20 June 2018

1 reference

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IRAK-M is a negative regulator of Toll-like receptor signaling

20 June 2018

1 reference

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The conformational plasticity of protein kinases

20 June 2018

1 reference

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IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103033

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

20 June 2018

1 reference

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Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase

20 June 2018

1 reference

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Kinetic and catalytic mechanisms of protein kinases

20 June 2018

1 reference

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Structural basis for control by phosphorylation

20 June 2018

1 reference

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

20 June 2018

1 reference

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IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

20 June 2018

1 reference

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

20 June 2018

1 reference

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Autoregulatory mechanisms in protein-tyrosine kinases

20 June 2018

1 reference

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Essential dynamics of DNA containing a cis.syn cyclobutane thymine dimer lesion.

20 June 2018

1 reference

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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103033

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

20 June 2018

1 reference

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Crystal structure of the Src family tyrosine kinase Hck

20 June 2018

1 reference

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Three-dimensional structure of the tyrosine kinase c-Src

20 June 2018

1 reference

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An efficient method for sampling the essential subspace of proteins.

20 June 2018

1 reference

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Structural basis of cyclin-dependent kinase activation by phosphorylation

20 June 2018

1 reference

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VMD: visual molecular dynamics

20 June 2018

1 reference

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Active and inactive protein kinases: structural basis for regulation

20 June 2018

1 reference

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Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I

20 June 2018

1 reference

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IRAK: a kinase associated with the interleukin-1 receptor

20 June 2018

1 reference

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Crystal structure of cyclin-dependent kinase 2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103033

Essential dynamics of proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103033

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

20 June 2018

1 reference

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Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103033

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

20 June 2018

1 reference

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Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components

20 June 2018

1 reference

IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses.

21 January 2018

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Atomistic view of the conformational activation of Src kinase using the string method with swarms-of-trajectories

21 January 2018

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Anatomy of a structural pathway for activation of the catalytic domain of Src kinase Hck

21 January 2018

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Phosphorylation and ATP-binding induced conformational changes in the PrkC, Ser/Thr kinase from B. subtilis

21 January 2018

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The active conformation of the PAK1 kinase domain

21 January 2018

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GROMACS: A message-passing parallel molecular dynamics implementation

21 January 2018

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Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

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Essential dynamics of the cellular retinol-binding protein--evidence for ligand-induced conformational changes.

21 January 2018

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Protein Conformational Transitions: The Closure Mechanism of a Kinase Explored by Atomistic Simulations

21 January 2018

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Molecular Dynamics Simulations and Elastic Network Analysis of Protein Kinase B (Akt/PKB) Inactivation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25034608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25034608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Solving the IRAK-4 enigma: application of kinase-dead knock-in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25034608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP05748

1 reference

Dimensions Publication ID

19 October 2017

0 references

1 reference

19 October 2017

PubMed publication ID

25034608

1 reference