The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells (Q30580446)

21 September 2017

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells (English)

1 reference

21 September 2017

Oanh H Do

1

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Peter Thorn

object named as

Peter Thorn

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4

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author name string

Jiun T Low

series ordinal

2

1 reference

21 September 2017

Herbert Y Gaisano

series ordinal

3

1 reference

21 September 2017

language of work or name

1 reference

6 April 2014

1 reference

21 September 2017

1 reference

21 September 2017

57

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21 September 2017

7

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21 September 2017

1400-1409

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Creative Commons Attribution 4.0 International

21 September 2017

start time

6 April 2014

1 reference

April 2022 Public Data File from Crossref

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copyrighted

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cites work

Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell

1 reference

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Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure

20 June 2018

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Ultra-structural study of insulin granules in pancreatic β-cells of db/db mouse by scanning transmission electron microscopy tomography

20 June 2018

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Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

20 June 2018

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Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion

20 June 2018

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Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms

20 June 2018

1 reference

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Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2 ) channels from secretory granules

20 June 2018

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Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

20 June 2018

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Novel aspects of the molecular mechanisms controlling insulin secretion

20 June 2018

1 reference

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Ca2 -secretion coupling is impaired in diabetic Goto Kakizaki rats

20 June 2018

1 reference

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Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane

20 June 2018

1 reference

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Cx36-mediated coupling reduces beta-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics

20 June 2018

1 reference

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

20 June 2018

1 reference

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Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells

20 June 2018

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Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients

20 June 2018

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Mechanisms of dense core vesicle recapture following "kiss and run" ("cavicapture") exocytosis in insulin-secreting cells

20 June 2018

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Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion

20 June 2018

1 reference

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Kiss and run exocytosis of dense core secretory vesicles

20 June 2018

1 reference

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Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans

20 June 2018

1 reference

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Monitoring of exocytosis and endocytosis of insulin secretory granules in the pancreatic beta-cell line MIN6 using pH-sensitive green fluorescent protein (pHluorin) and confocal laser microscopy

20 June 2018

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Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretion

20 June 2018

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Abnormal splicing of the leptin receptor in diabetic mice

20 June 2018

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Defective glucose-dependent endoplasmic reticulum Ca2 sequestration in diabetic mouse islets of Langerhans.

20 June 2018

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The Possible Importance of Contact between Pancreatic Islet Cells for the Control of Insulin Release*

20 June 2018

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Influence of the mutation "diabetes" on insulin release and islet morphology in mice of different genetic backgrounds

20 June 2018

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The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4052007

Development of the insulin secretory defect in genetically diabetic (db/db) mouse

20 June 2018

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Alteration of Islet Cell Populations in Spontaneously Diabetic Mice

20 June 2018

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Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice: Possible protection of beta cells from oxidative stress

20 June 2018

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Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

21 January 2018

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Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00125-014-3226-8

Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00125-014-3226-8

TIRF imaging of docking and fusion of single insulin granule motion in primary rat pancreatic beta-cells: different behaviour of granule motion between normal and Goto-Kakizaki diabetic rat beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00125-014-3226-8

Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00125-014-3226-8

Two phases of zymogen granule lifetime in mouse pancreas: ghost granules linger after exocytosis of contents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00125-014-3226-8

Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00125-014-3226-8

Pancreatic beta cells from db/db mice show cell-specific [Ca2 ]i and NADH responses to glucose but not to alpha-ketoisocaproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00125-014-3226-8

Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00125-014-3226-8

Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4052007

Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4052007

10.1007/S00125-014-3226-8

26 November 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

21 September 2017

0 references

1 reference

21 September 2017

PubMed publication ID

24705605

1 reference