The parkinsonian neurotoxin MPP opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. (Q30473178)

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English	The parkinsonian neurotoxin MPP opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism.	scientific article

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12 December 2019

The parkinsonian neurotoxin MPP opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism (English)

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12 December 2019

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Parkinson's disease

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David S Cassarino

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12 December 2019

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J K Parks

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12 December 2019

W D Parker

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12 December 2019

J P Bennett

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12 December 2019

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1 January 1999

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12 December 2019

Biochimica et Biophysica Acta

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12 December 2019

1453

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12 December 2019

1

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12 December 2019

49-62

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12 December 2019

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

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7 January 2021

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The mitochondrial permeability transition.

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The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal

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The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

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7 January 2021

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Opening of the mitochondrial permeability transition pore by uncoupling or inorganic phosphate in the presence of Ca2 is dependent on mitochondrial-generated reactive oxygen species.

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Effect of inorganic phosphate concentration on the nature of inner mitochondrial membrane alterations mediated by Ca2 ions. A proposed model for phosphate-stimulated lipid peroxidation.

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Mechanisms by which mitochondria transport calcium

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The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

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Exposure to the parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP ) and nitric oxide simultaneously causes cyclosporin A-sensitive mitochondrial calcium efflux and depolarisation

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On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide.

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Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.

1 reference

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Ca(2 )-induced mitochondrial membrane permeabilization: role of coenzyme Q redox state

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Ca2 depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition.

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Inhibition of Ca2( )-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

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Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2 : correlation with mitochondrial permeability transition

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Origin and functional consequences of the complex I defect in Parkinson's disease

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Point mutations of mitochondrial genome in Parkinson's disease

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Abnormalities of the electron transport chain in idiopathic Parkinson's disease

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Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

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Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson's disease

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Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease

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Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease

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Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

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Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease

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Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease

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Mechanism of the neurotoxicity of MPTP. An update

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Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

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MPTP-induced oxidative stress and neurotoxicity are age-dependent: evidence from measures of reactive oxygen species and striatal dopamine levels

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Mitochondrial respiratory chain inhibitors induce apoptosis.

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Apoptosis is induced by 1-methyl-4-phenylpyridinium ion (MPP ) in ventral mesencephalic-striatal co-culture in rat.

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Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons

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Protection by cyclosporin A of cultured hepatocytes from the toxic consequences of the loss of mitochondrial energization produced by 1-methyl-4-phenylpyridinium

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Bioenergetic and oxidative stress in neurodegenerative diseases

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Parkinson's disease and free radicals. Mechanism of neurodegeneration and neuroprotection

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Mitochondrial control of nuclear apoptosis.

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Mitochondrial permeability transition is a central coordinating event of apoptosis

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Redox regulation of apoptosis: impact of thiol oxidation status on mitochondrial function.

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Ca2 and cell death

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Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

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7 January 2021

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Release of cytochrome c from liver mitochondria during permeability transition.

1 reference

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Mitochondrial Permeability Transition in the Central Nervous System: Induction by Calcium Cycling‐Dependent and ‐Independent Pathways

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Enzymatic properties of the inner and outer membranes of rat liver mitochondria

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Preparation of synaptic and nonsynaptic mitochondria from mammalian brain

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inferred from DOI database lookup

The peptide mastoparan is a potent facilitator of the mitochondrial permeability transition

1 reference

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7 January 2021

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Molecular proportion of the fixed cytochrome components of the respiratory chain of Keilin-Hartree particles and beef heart mitochondria

1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Reduction of MPP( )-induced hydroxyl radical formation and nigrostriatal MPTP toxicity by inhibiting nitric oxide synthase.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Relationships between the mitochondrial transmembrane potential, ATP concentration, and cytotoxicity in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016/S0925-4439(98)50083-0

7 January 2021

based on heuristic

inferred from DOI database lookup

MPP and MPDP induced oxygen radical formation with mitochondrial enzymes.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ca(2 )-triggered membrane permeability transition in deenergized mitochondria from rat liver

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of Ca 2 release from mitochondria by the oxidation-reduction state of pyridine nucleotides

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Butylated hydroxytoluene and inorganic phosphate plus Ca2 increase mitochondrial permeability via mutually exclusive mechanisms

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Selective inhibition of the mitochondrial permeability transition pore at the oxidation-reduction sensitive dithiol by monobromobimane

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of a Caspase‐3‐Like Cysteine Protease in 1‐Methyl‐4‐Phenylpyridinium‐Mediated Apoptosis of Cultured Cerebellar Granule Neurons

1 reference

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7 January 2021

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inferred from DOI database lookup

Identifiers

10.1016/S0925-4439(98)00083-0

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9989245 AND SRC:MED&resulttype=core&format=json

12 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9989245 AND SRC:MED&resulttype=core&format=json

12 December 2019

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