Update on molecular findings, management and outcome in low-grade gliomas (Q30452178)

21 June 2017

title

Update on molecular findings, management and outcome in low-grade gliomas (English)

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21 June 2017

T David Bourne

1

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21 June 2017

David Schiff

series ordinal

2

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21 June 2017

language of work or name

English

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publication date

2 November 2010

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21 June 2017

published in

Nature Reviews Neurology

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21 June 2017

volume

6

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21 June 2017

issue

12

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21 June 2017

page(s)

695-701

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Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas.

21 June 2017

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What is an oligodendroglioma?

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Longitudinal assessment of genetic and epigenetic markers in oligodendrogliomas

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Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations

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Molecular markers of prognosis in astrocytic tumors

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Clinical and molecular characteristics of malignant transformation of low-grade glioma in children

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Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma

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New insight into BRAF mutations in cancer

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Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma

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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

31 March 2020

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Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas

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Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

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Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma

31 March 2020

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Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

31 March 2020

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An integrated genomic analysis of human glioblastoma multiforme

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

31 March 2020

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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31 March 2020

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Analysis of the IDH1 codon 132 mutation in brain tumors

31 March 2020

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IDH1 and IDH2 mutations in gliomas

31 March 2020

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IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

31 March 2020

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IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas

31 March 2020

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Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

31 March 2020

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IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors

31 March 2020

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Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

31 March 2020

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Recurring mutations found by sequencing an acute myeloid leukemia genome

31 March 2020

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

31 March 2020

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IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

31 March 2020

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Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome

31 March 2020

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Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues

31 March 2020

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Monoclonal antibody specific for IDH1 R132H mutation

31 March 2020

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Mutant IDH1-specific immunohistochemistry distinguishes diffuse astrocytoma from astrocytosis

31 March 2020

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Surgery Insight: the role of surgery in the management of low-grade gliomas

31 March 2020

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Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas

31 March 2020

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Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial

31 March 2020

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Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up

31 March 2020

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Correlation between genetic alteration and long‐term clinical outcome of patients with oligodendroglial tumors, with identification of a consistent region of deletion on chromosome arm 1p

31 March 2020

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Survival analysis of presumptive prognostic markers among oligodendrogliomas.

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2010.159

The impact of genotype on outcome in oligodendroglioma: validation of the loss of chromosome arm 1p as an important factor in clinical decision making

31 March 2020

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Molecular pathology and clinical characteristics of oligodendroglial neoplasms

31 March 2020

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Reclassification of oligoastrocytomas by loss of heterozygosity studies.

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2010.159

Temozolomide three weeks on and one week off as first line therapy for patients with recurrent or progressive low grade gliomas

31 March 2020

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Phase II study of protracted daily temozolomide for low-grade gliomas in adults

31 March 2020

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Chromosome 1p and 19q status and p53 and p16 expression patterns as prognostic indicators of oligodendroglial tumors: a clinicopathological study using fluorescence in situ hybridization

31 March 2020

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Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?

31 March 2020

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Correlation among pathology, genetic and epigenetic profiles, and clinical outcome in oligodendroglial tumors.

31 March 2020

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Retrospective review of prognostic factors, including 1p19q deletion, in low-grade oligodendrogliomas and a review of recent published works

31 March 2020

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Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions

31 March 2020

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Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression

31 March 2020

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Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities

31 March 2020

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Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine

31 March 2020

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Low-grade gliomas in older patients: a retrospective analysis of prognostic factors

31 March 2020

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IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2010.159

All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/NRNEUROL.2010.159

IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2010.159

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

31 March 2020

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https://api.crossref.org/works/10.1038/NRNEUROL.2010.159

Immunocytochemical mapping of the phosphatase and tensin homolog (PTEN/MMAC1) tumor suppressor protein in human gliomas

31 March 2020

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12 December 2020

Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: observer variability and lack of association with patient survival impede its use as clinical biomarker

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12 December 2020

Promoter Hypermethylation of the DNA Repair Gene O6‐Methylguanine‐DNA Methyltransferase is an Independent Predictor of Shortened Progression Free Survival in Patients with Low‐grade Diffuse Astrocytomas

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12 December 2020

Characterisation of molecular alterations in microdissected archival gliomas.

1 reference

12 December 2020

Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival.

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12 December 2020

Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene

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12 December 2020

Pten signaling in gliomas

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12 December 2020

O6-methylguanine-DNA methyltransferase in human brain tumors detected by activity assay and monoclonal antibodies.

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12 December 2020

10.1038/NRNEUROL.2010.159

Identifiers

DOI

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Dimensions Publication ID

21 June 2017

1026853007

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